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Novel scaffold for cathepsin K inhibitors.

Teno, Naoki and Miyake, Takahiro and Ehara, Takeru and Irie, Osamu and Sakaki, Junichi and Ohmori, Osamu and Gunji, Hiroki and Matsuura, Naoko and Masuya, Keiichi and Hitomi, Yuko and Nonomura, Kazuhiko and Horiuchi, Miyuki and Gohda, Keigo and Iwasaki, Atsuko and Umemura, Ichiro and Tada, Sachiyo and Kometani, Motohiko and Iwasaki, Genji and Cowan-Jacob, Sandra and Missbach, Martin and Lattmann, Rene and Betschart, Claudia (2007) Novel scaffold for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 17 (22). pp. 6096-6100. ISSN 0960-894X


Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Cathepsin K inhibitors; Pyrrolopyrimidine; Novel scaffold
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Date Deposited: 14 Dec 2009 14:01
Last Modified: 31 Jan 2013 01:18


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