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Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells.

Graf, Christine and Rovina, Philipp and Tauzin, Loic and Schanzer, Andrea and Bornancin, Frederic (2007) Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells. Biochemical and Biophysical Research Communications, 354 (1). pp. 309-314. ISSN 0006-291X

Abstract

We evaluated how increased levels of ceramide kinase (CerK) would impact the growth of COS-1 fibroblasts and RBL-2H3 basophils. The low CerK activity in these cells was strongly up-regulated upon recombinant expression of CerK. CerK-overexpressing COS-1 cells depended on higher concentrations of serum for their growth and displayed many filipodia. The two CerK-overexpressing cell lines were more sensitive to C2-ceramide-mediated apoptosis, and this correlated with the production of C2-ceramide-1-phosphate by CerK. This study indicates that ceramide kinase may participate in the control of cell growth, and establishes a novel assay that will be valuable for testing ceramide kinase inhibitors.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Ceramide; Ceramide-1-phosphate; Apoptosis; Differentiation; Proliferation
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Date Deposited: 14 Dec 2009 13:58
Last Modified: 31 Jan 2013 01:14
URI: https://oak.novartis.com/id/eprint/545

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