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4-Aminopyrimidines as novel HIV-1 inhibitors.

Gadhachanda, Venkat, Wu, Baogen, Wang, Zhiwei, Kuhen, Kelli, Caldwell, Jeremy, Zondler, Helmut, Walter, Harald, Havenhand, Mark and He, Yun (2007) 4-Aminopyrimidines as novel HIV-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 17 (1). pp. 260-265. ISSN 0960-894X


A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Aminopyrimidine; HIV-1 inhibitor
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Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:26


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