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Identification of a series of highly potent activators of the Nurr1 signaling pathway.

Hintermann, Samuel and Chiesi, Michele and Von Krosigk, Ulrike and Mathe, Daniele and Felber, Richard and Hengerer, Bastian (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorganic & Medicinal Chemistry Letters, 17 (1). pp. 193-196. ISSN 0960-894X

Abstract

The nuclear receptor Nurr1 (NR4A2) is critically involved in the development and maintenance of midbrain dopaminergic neurons and is believed to function independently of endogenous activation. The hit identification and SAR studies leading to isoxazolo-pyridinone 7e, a highly potent, brain penetrable activator of the Nurr1 signaling pathway, are described.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Nurr1 activation; Parkinson’s Disease
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Date Deposited: 14 Dec 2009 13:57
Last Modified: 31 Jan 2013 01:12
URI: https://oak.novartis.com/id/eprint/584

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