Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Items where Year is 2023

Group by: Creators | Item Type | No Grouping
Jump to: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
Number of items: 300.

A

Aaron, Buaben and Pelis, Ryan (2023) Incubation Time Influences Organic Anion Transporter 1 Kinetics In Vitro and Renal Clearance Predictions for Para-Aminohippurate. Journal of xenobiotics., 13. pp. 205-217. ISSN 2039-4713

Altevogt, Dominik, Cedillo, Isaiah, Curtis, Corrine, Diorazio, Louis, Faber, Jesse, Jones, Michael, Telford, Alex, Turner, Gillian and Wetter, Christian (2023) Platform Strategies for Synthetic Oligonucleotides. Organic Process Research & Development, 27 (12). pp. 2211-2222. ISSN 1083-61601520-586X

Amara, Kenza, Rodriguez Perez, Raquel and Jimenez-Luna, Jose (2023) Explaining compound activity predictions with a substructure-aware loss for graph neural networks. Journal of cheminformatics. ISSN 1758-2946

Amara, Kenza, Rodriguez Perez, Raquel and Jimenez-Luna, Jose (2023) Explaining compound activity predictions with a substructure-aware loss for graph neural networks. Journal of cheminformatics, 15 (1). p. 67. ISSN 1758-2946

An, Shaojian, Axford, Jake, Benander, Christina, Bergsdorf, Christian, Botsch, Josephine, Chau, Suzanne, Fernandez, Cesar, Gleim, Scott, Hassiepen, Ulrich, Hunziker, Juerg, Joly, Emilie, Keller, Aramis, Lopez Romero, Sandra, Maher, Rob, Mangold, Anne-Sophie, Mickanin, Craig, Mihalic, Manuel, Neuner, Philippe, Patterson, Andrew, Perruccio, Francesca, Roggo, Silvio, Scesa, Julien, Schroeder, Martin, Shkoza, Dojna, Thai, Binh, Vulpetti, Anna, Renatus, Martin and Reece-Hoyes, John S. (2023) Discovery of ligands for TRIM58, a novel tissue selective E3 ligase. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Anders, Hans-Joachim, Roesti, David, Mohammadi, Mahsa and Bauer, Aline (2023) A rapid sterility method using solid phase cytometry for cell based preparations and culture media and buffers. PDA Journal of Pharmaceutical Science and Technology. ISSN 1079-74401948-2124

Arnold, Liz, Soler-Llavina, Gil, Kambara, Kumiko and Bertrand, Daniel (2023) The importance of ligand gated ion channels in sleep and sleep disorders. Biochemical pharmacology, 212. p. 115532. ISSN 1873-2968

Auberson, Yves, Arimoondo, Paola, Duca, Maria, Essig, Sebastian, Grether, Uwe, Rufer, Arne, Sbardella, Gianluca, Schopfer, Ulrich, Torrens, Antoni, van der Stelt, Mario, Vauzeilles, Boris, Vazquez, Olalla and Zhang, Andrew (2023) EFMC: Trends in Medicinal Chemistry and Chemical Biology. Chembiochem : a European journal of chemical biology. e202200690. ISSN 1439-7633

Auberson, Yves, Benfatti, Fides, Gillingham, Dennis and Hartrampf, Nina (2023) An active member of EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society. ChemMedChem : chemistry enabling drug discovery. ISSN 1860-7187; 1860-7179

Auberson, Yves, Grether, Uwe, Vauzeilles, Boris and Vazquez, Olalla (2023) Mutually Rewarding Academia-Industry Collaborations in the Field of Chemical Biology. ChemBioChem.

Awoonor-Williams, Ernest, Dickson, Callum, Furet, Pascal, Golosov, Andrei and Hornak, Viktor (2023) Molecular Insights into the Binding Interaction of the First Class of Potent Small Molecules Disrupting the YAP-TEAD Protein-Protein Interaction. Journal of chemical information and modeling. ISSN 1549-960X; 1549-9596

B

Bagdanoff, Jeffrey, Smith, Thomas, Allan, Martin, O'Donnell, Peter, Nguyen, Zachary, Moore, Elizabeth, Baird, Jason, Wang, Shuangxi, Subramanian, Vanitha, Tigani, Bruno, Nettleton, David, Monovich, Lauren, Lewis, Ian, Flyer, Alec, Granda, Brian, Blankenship, John, Barnes-Seeman, David and Clairmont, Kevin (2023) Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands. Cell chemical biology, 30 (1). 97-109.e9. ISSN 2451-9448

Bal, Gobardhan (2023) Characterization and Reverse Engineering of Pharmaceuticals: Role of Thermoanalytical Techniques. Research Journal of Pharmacy and Technology, 16 (10). pp. 4973-4980. ISSN 0974-360X,0974-3618

Bal, Gobardhan (2023) Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studies. Xenobiotica; the fate of foreign compounds in biological systems. pp. 1-13. ISSN 1366-5928

Bampali, Konstantina, Filip, Koniuszewski, Vogel, Florian, Fabian, Jure, Andronis, Christos, Lekka, Eftychia, Virvillis, Vassiis, Seidel, Thomas, Delaunois, Annie, Royer, Leandro, Rolf, Mike, Giuliano, Chiara, Traebert, Martin, Roussignol, Gautier, Fric-Bordat, Magali, Mazelin-Winum, Ludmilla, Bryant, Sharon, Langer, Thierry and Ernst, Margot (2023) GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach. Cell biology and toxicology. ISSN 1573-6822

Barbosa, Ines, Gopalakrishnan, Rajaraman, Mercan, Samuele, Mourikis, Thanos, Martin, Typhaine, Wengert, Simon, Sheng, Caibin, Ji, Fei, Lopes, Rui, Knehr, Judith, Altorfer, Marc, Lindeman, Alicia, Russ, Carsten, Naumann, Ulrike, Golji, Javad, Sprouffske, Kathleen, Barys, Louise, Schmelzle, Tobias and Galli, Giorgio (2023) Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens. Nature communications, 14 (1). p. 3907. ISSN 2041-1723

Basu, Sumit, Ren, Xiaojun and Dodd, Stephanie (2023) Streamlining Food Effect Assessment — Are Repeated Food Effect Studies Needed? An IQ Analysis. Journal of Pharmaceutical Sciences, 25 (60).

Bechtold-Peters, Karoline, Moll, Fabian and Friess, Wolfgang (2023) Evaluation of a novel silicone oil free primary packaging system with PTFE-based barrier stopper for biologics. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 190. pp. 206-219. ISSN 1873-3441

Bechtold-Peters, Karoline, Moll, Fabian and Friess, Wolfgang (2023) Impact of autoclavation on baked-on siliconized containers for biologics. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 187. pp. 184-195. ISSN 1873-3441

Bechtold-Peters, Karoline, Niu, Sue, Schweizer, Daniel, Buecheler, Jakob, Brouillard, Christian, Callaway, Allen, Desai, Priyanka, Duggan, Naomi, Feng, Yiqing, Ihle, Nathan, Jacobson, Fred, Liu, Denfeng, Mayala, Padma, Morgan, Charles, Panek, Mark, Ruggiero, Andrea, Wright, Mark, Vriezen, Nienke and Wang, Xiangyang (2023) CMC Regulatory Considerations for Antibody-Drug Conjugates. Journal of pharmaceutical sciences. ISSN 1520-6017

Beckers, Maximilian, Lanini, Jessica, Schneider, Nadine, Gregory, Landrum, Sereina, Riniker and Nikolaus, Stiefl (2023) SIMPD: an algorithm for generating simulated time splits for validating machine learning approaches. Journal of cheminformatics, 15 (1). p. 119. ISSN 1758-2946

Beckers, Maximilian, Sturm, Noe, Sirockin, Finton, Fechner, Nikolas and Stiefl, Nikolaus (2023) Prediction of Small-Molecule Developability Using Large-Scale In Silico ADMET Models. Journal of medicinal chemistry. ISSN 1520-4804

Beckmann, Nicolau (2023) Editorial for "MRI Fat-Saturated T2-Weighted Radiomics Model for Predicting the Ki-67 Index of Soft Tissue Sarcomas”. Journal of magnetic resonance imaging, 58 (2). pp. 546-547. ISSN 10.1002/jmri.28563

Beckmann, Nicolau (2023) Editorial for "The effects of respiratory muscle training on resting state brain activity and thoracic mobility in healthy subjects: a randomized controlled trial”. Journal of magnetic resonance imaging, 57 (2). pp. 418-419. ISSN 1522-2586

Beckmann, Nicolau, Neuhaus, Anna, Zurbruegg, Stefan, Joller, Stefanie, Feuerbach, Dominik, Doelemeyer, Arno, Volkmer, Pia, Schweizer, Tatjana, Rudin, Stefan, Patino, Claudia, Neumann, Ulf, Berth, Ramon, Frieauff, Wilfried, Gasparini, Fabrizio and Shimshek, Derya (2023) Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation, 20 (1). p. 29. ISSN 1742-2094

Behera, Susrisweta, Veselý, Lukáš, Štůsek, Radim, Hauptmann, Astrid, Loerting, Thomas and Heger, Dominik (2023) Investigating freezing-induced acidity changes in citrate buffers. International journal of pharmaceutics, 643. p. 123211. ISSN 1873-3476

Beil, Johanna, Perner, Juliane, Pfaller, Lena, Gerard, Marie-Apolline, Piaia, Alessandro, Doelemeyer, Arno, Wasserkrug, Adi, Martin, Lori, Piequet, Aline, Dubost, Valerie, Moggs, Jonathan and Terranova, Remi (2023) Unaltered hepatic wound healing response in male rats with ancestral liver injury. Nature communications, 14 (1). p. 6353. ISSN 2041-1723

Bennet, Bindu, Pardo, Ingrid, Assaf, Basel, Buza, Elizabeth, Cramer, Sarah, Crawford, LaTasha, Engelhardt, Jefferey, Galbreath, Elizabeth, Grubor, Branka, Morrison, James, Osborne, Tanasa, Sharma, Alok and Bolon, Brad (2023) Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing. Toxicologic pathology, 51 (5). pp. 278-305. ISSN 1533-1601

Bepperling, Alexander (2023) Comparison of three AUC techniques for the determination of the loading status and capsid titer of AAVs. European biophysics journal : EBJ. ISSN 1432-1017

Bepperling, Alexander and Richter, Gesa (2023) Determination of mRNA copy number in degradable lipid nanoparticles via density contrast analytical ultracentrifugation. European biophysics journal : EBJ. ISSN https://doi.org/10.1007/s00249-023-01663-y

Beri, Pranjali, Plunkett, Christopher, Barbara, Joshua, Shih, Chien-Cheng, Barnes, Whitney, Ross, Olivia, Choconta, Paula, Trinh, Ton, Gomez, Datzael, Litvin, Bella, Walker, John, Qiu, Minhua, Hammack, Scott and Toyama, Erin (2023) A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma. APL bioengineering, 7 (2). 026104. ISSN 2473-2877

Beri, Pranjali, Plunkett, Christopher, Barbara, Joshua, Shih, Michael, Barnes, Whitney, Ross, Olivia, Choconta, Paula, Trinh, Ton, Litvin, Bella, Walker, John, Qiu, Minhua, Hammack, Scott and Toyama, Erin (2023) A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma. APL bioengineering, 7 (2). 026104. ISSN 2473-2877

Beri, Pranjali, Woo, Young, Schierenbeck, Katie, Chen, Kaisheng, Barnes, Whitney, Ross, Olivia, Krutil, Douglas, Quackenbush, Doug, Fang, Bin, Walker, John, Barnes, William and Toyama, Erin (2023) A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening. PloS one, 18 (6). e0287809. ISSN 1932-6203

Bickel, Fabian, Griaud, Francois, Kern, Wolfram, Kroener, Frieder, Gritsch, Manuela, Dayer, Jerome, Barteau, Samuel, Denefeld, Blandine, Kao-Scharf, Chi-Ya, Lang, Manuel, Slupska-Muanza, Izabela, Schmidt, Carla, Berg, Matthias, Sigg, Juergen, Boado Chaves, Lina and Chelius, Dirk (2023) Restoring the biological activity of crizanlizumab at physiological conditions through a pH-dependent aspartic acid isomerization reaction. mAbs, 15 (1). 0-0. ISSN 1942-0862

Bier, Katharina, Senajova, Zuzana, Henrion, Fanny, Wang, Yichen, Bruno, Sandro, Rauld, Celine, Hoermann, Lisa, Barske, Carmen, Delucis-Bronn, Corinne, Bergling, Sebastian, Altorfer, Marc, Haegele, Jasmin, Knehr, Judith, Junt, Tobias, Roediger, Ben, Roehn, Till and Kolbinger, Frank (2023) Interleukin-26 potentiates type 2 skin inflammation in presence of interleukin-1β. Interleukin-26 potentiates type 2 skin inflammation in presence of interleukin-1β.

Bigaud, Marc, Ramseier, Pamela, Tisserand, Sarah, Lang, Meike, Urban, Beatrice, Beerli, Christian and Karlsson, Goeril (2023) Central versus peripheral drug exposure ratio, a key differentiator for siponimod over fingolimod ? Neurology and Therapy. ISSN 2193-6536; 2193-8253

Blank, Jutta, Blechschmidt, Anke, Boettcher, Andreas, Bornancin, Frederic, Brady, Jacob, Eder, Joerg, Freuler, Felix, Haenni-Holzinger, Sandra, Hediger, Michael, Hommel, Ulrich, Hurth, Konstanze, Kaiser, Christian, Koch, Elke, Lehmann, Sylvie, Lehr, Philipp, Lingel, Andreas, Ostermeier, Daniela, Ramage, Paul, Rondeau, Jean-Michel, Tundo Dottorello, Valentina, Vulpetti, Anna, Yamamoto, Rina, Mureddu, Luca and Schleberger, Christian (2023) Discovery of a selective and biologically active low-molecular weight antagonist of human IL-1b. Nature communications, 14. pp. 5497-5509.

Blatter, Markus, Meylan, Charlotte, Cléry, Antoine, Giambruno, Roberto, Nikolaev, Yaroslav, Heidecker, Michel, Solanki, Jessica Arvindbhai, Diaz, Manuel, Gabellini, Davide and Allain, Frédéric H.-T. (2023) RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Science advances, 9 (16). eadf5330. ISSN 2375-2548

Bluemel, Markus and Gasser, Florian (2023) Current Industry Best Practice on In-Use Stability and Compatibility Studies of Biological Products. Journal of pharmaceutical sciences.

Bluemel, Markus and Gasser, Florian (2023) Current Industry Best Practice on in-use Stability and Compatibility Studies for Biological Products. Journal of pharmaceutical sciences. ISSN 1520-6017

Bordawekar, Mangesh, Pudipeddi, Madhu, Ruegger, Colleen and Dhareshwar, Sundeep (2023) Formulation intervention to overcome decreased kinetic solubility of a low Tg amorphous drug. Formulation intervention to overcome decreased kinetic solubility of a low Tg amorphous drug, 24.

Bornancin, Frederic and Dekker, Carien (2023) A Phospho-harmonic Orchestra Plays the NLRP3 Score. Frontiers in immunology.

Brenner, Anne, Brookbank, J.D. and Wang, Yingqi (2023) Faces of Mass Spectrometry/Karen Wang. Journal of the American Society for Mass Spectrometry, 34 (7). pp. 1207-1209. ISSN 1879-1123

Bretz, Frank (2023) The Role of Statistical Thinking in Biopharmaceutical Research. Statistics in biopharmaceutical research.

Brogdon, Jennifer, Engels, Boris, Mansfield, Keith, Zhao, Linlin, Granda, Brian, Taraszka, John, Ramones, Melissa and Xu, Fangmin (2023) Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells. Molecular therapy : the journal of the American Society of Gene Therapy, 31 (8). pp. 2309-2325. ISSN 1525-0024

Brosig, Sebastian, Cucuzza, Stefano, Serno, Tim, Bechtold-Peters, Karoline, Buecheler, Jakob, Zivec, Matej, Germershaus, Oliver and Gallou, Fabrice (2023) Not the Usual Suspects: Alternative Surfactants for Biopharmaceuticals. ACS applied materials & interfaces. ISSN 1944-8252

Buntin, Kathrin, Mrak, Peter, Pivk-Lukancic, Petra, Wollbrett, Severine, Drčar, Tjaša, Krastel, Philipp, Thibaut, Christian, Salcius, Michael, Gao, Xiaolin, Wang, Shaowen, Weber, Eric and Regenass, Hugo (2023) Generation of bioactivity-tailored FK506/FK520 analogs by CRISPR editing in Streptomyces tsukubaensis. Chemistry a european journal, 30 (3). n/a-n/a. ISSN 0947-6539

Burstedt, Marie, Whelan, James, Green, Jane, Holopigian, Karen, Spera, Claudio, Greco, Erin, Deslandes, Jean-Yves, Wald, Michael, Grosskreutz, Cyndy, Ni, Xiao, Meyers-Normand, Guillaume, Maker, Michael, Charil, Arnaud, Rosol, Michael, He, Yunsheng and Stasi, Kalliopi (2023) Retinal dystrophy associated with RLBP1 retinitis pigmentosa: A 5-year prospective natural history study. investigative Ophthalmology and vision science, 64 (13). pp. 1-13. ISSN Online ISSN: 1552-5783

Böhringer, David, Moravec, Ivana, Rausch, Martin, Fabry, Ben, Kah, Kah and Bauer, Andreas (2023) Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility. Matrix biology : journal of the International Society for Matrix Biology, 124. pp. 39-48. ISSN 1569-1802

C

Canham, Steve and Feng, Yan (2023) Activation of human STING by a molecular glue-like compound. Nature chemical biology. ISSN 1552-4469; 1552-4450

Canham, Steve, Feng, Yan, Cho, Charles and Hornak, Viktor (2023) Activation of human STING by a molecular glue-like compound. Nature chemical biology.

Carmen, Pessuti, Medley, Quintus, Li, Ning, Huang, Chia-Ling, Loureiro, Joe, Banks, Angela, Zhang, Qin, Costa, Deise, Ribeiro, Kleber, Nascimento, Heloisa, Muccioli, Cristina, Commodaro, Alessandra, Huang, Qian and Belfort, Rubens (2023) Differential proteins expression distinguished between patients with infectious and noninfectious uveitis. Ocular Immunology & Inflammation. ISSN 0927-3948 , 1744-5078

Chand, Deepa, Sun, Rui, Tukov, Francis, Damien, Kenny and Karim, Diab (2023) Review of cardiac safety in onasemnogene abeparvovec gene replacement therapy: translation from preclinical to clinical findings. Gene therapy. pp. 1-13. ISSN 1476-5462

Chapeau, Emilie and Schmelzle, Tobias (2023) IAG933, an oral selective YAP1-TAZ/pan-TEAD protein-protein interaction inhibitor (PPIi) with pre-clinical activity in monotherapy and combinations with MAPK inhibitors. Nature cancer.

Chen, Yao and Xi, Dong (2023) Optimal weighted Bonferroni tests and their graphical extensions. Statistics in Medicine. ISSN 0277-67151097-0258

Chen, Yue, Ge, Ying, Hao, Ling, Han, Xianlin, Huan, Tao, Li, Liang, Li, Lingjun, Li, Wenkui, Liang, Xiaorong, Lin, Yanping, Liu, Xiaowen, Liu, Yansheng, Ma, Shuguang, Peng, Junmin, Shou, Wilson, Sun, Liangliang, Tao, Andy W., Tian, Yu, Wang, Karen, Wang, Yinsheng, Wu, Ronghu, Wu, Si, Xia, Jianguo, Yang, Zhibo, Zhang, Hui, Zhang, Hui, Weng, Naidong and Huang, Lan (2023) Meeting Report on the 2nd Chinese American Society for Mass Spectrometry (CASMS) Conference. Molecular & cellular proteomics : MCP, 22 (6). pp. 1-13. ISSN 1535-9476

Chie Leon, Barbara, Dovala, Dustin, Luu, Catherine, Pardee, Gwynn, Widger, Stephania, Ornelas, Elizabeth, Solomon, Jonathan, Moser, Heinz, Clifton, Matt, Wartchow, Charles, Ma, Xiaolei, Beckwith, Rohan and Tandeske, Laura (2023) Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Nature Scientific Reports.

Concannon, John, Aspesi Jr, Peter, Cimini, Beth, Chandrasekaran, Srinivas, Kost-Alimova, Maria, Miller, Lisa, Goodale, Amy, Fritchman, Briana, Byrne, Patrick, Garg, Sakshi, Jamali, Nasim, Logan, David, Lardeau, Charles-Hugues, Mouchet, Elizabeth, Singh, Shantanu, Shafqat Abbasi, Hamdah, Boyd, Justin, Gilbert, Tamara, Gnutt, David, Hariharan, Santosh, Hernandez, Desiree, Hormel, Gisela, Juhani, Karolina, Melanson, Michelle, Mervin, Lewis, Monteverde, Tiziana, Pilling, James, Skepner, Adam, Swalley, Susanne, Vrcic, Anita, Weisbart, Erin, Williams, Guy, Yu, Shan, Zapiec, Bolek and Carpenter, Anne (2023) Optimizing the Cell Painting assay for image-based profiling. Nature methods, 18. pp. 1981-2013. ISSN 1750-2799

Cortés Hernández, Josefina, Barba, Pere, Linares Alberich, Monica, Fischer, Ozana, Kovacs, Beata, Calzascia, Thomas, Pearson, David, Jordan Garrotte, Ana-Laura, Kirsilae, Tiina, Siegel, Richard, Shisha, Tamas, Cavalli, Giulio and Gergely, Peter (2023) An Open-label, Multi-center, Phase 1/2 Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323, a Rapid Manufacturing CAR-T Cell Therapy Targeting CD19 on B Cells, for Severe Refractory Systemic Lupus Erythematosus: Preliminary Results. An Open-label, Multi-center, Phase 1/2 Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323, a Rapid Manufacturing CAR-T Cell Therapy Targeting CD19 on B Cells, for Severe Refractory Systemic Lupus Erythematosus: Preliminary Results.

Cucuzza, Stefano, Brosig, Sebastian, Serno, Tim, Bechtold-Peters, Karoline, Cerar, Jure, Kammueller, Michael and Gallou, Fabrice (2023) Modular and tunable alternative surfactants for biopharmaceuticals provide insights into Surfactant's Structure-Function relationship. International journal of pharmaceutics, 650. p. 123692. ISSN 1873-3476

Cucuzza, Stefano, Sitnik, Malgorzata, Jurt, Simon, Michel, Erich, Dai, Wenzhao, Müntener, Thomas, Ernst, Patrick, Häussinger, Daniel, Plückthun, Andreas and Zerbe, Oliver (2023) Unexpected dynamics in femtomolar complexes of binding proteins with peptides. Nature communications, 14 (1). p. 7823. ISSN 2041-1723

Cui, Elvis Han, Goldfine, Allison, Quinlan, Michelle, James, David and Sverdlov, Alex (2023) Investigating the value of glucodensity analysis of continuous glucose monitoring data in type 1 diabetes: An exploratory analysis. Frontiers in Clinical Diabetes and Healthcare.

D

Debon, Aaron, Siirola, Elina Maria and Snajdrova, Radka (2023) Enzymatic Bioconjugation: A Perspective from the Pharmaceutical Industry. JACS Au, 3 (5). pp. 1267-1283. ISSN 2691-3704

Demir, Andac, Khalil, Iya and Kiziltan, Bulent (2023) EEG-NEXT: A MODERNIZED CONVNET FOR THE CLASSIFICATION OF COGNITIVE ACTIVITY FROM EEG. 2023 IEEE International Conference on Acoustics, Speech and Signal Processing.

Di Lascio, Elena, Gerebtzoff, Gregori and Rodriguez Perez, Raquel (2023) Systematic Evaluation of Local and Global Machine Learning Models for the Prediction of ADME Properties. Molecular pharmaceutics. ISSN 1543-8392

Di Lascio, Elena, Gerebtzoff, Gregori and Rodriguez Perez, Raquel (2023) Systematic Evaluation of Local and Global Machine Learning Models for the Prediction of ADME Properties. Molecular pharmaceutics. ISSN 1543-8392

Di Lascio, Elena, Yonchev, Dimitar and Hamzic, Seid (2023) People of TM: Video Data Science Academy Fellows. You Tube.

Di Marco, Fiammetta, Bloechl, Constantin, Esser-Skala, Wolfgang, Schaepertoens, Veronika, Wuhrer, Manfred, Sandra, Koen, Wohlschlager, Therese and Huber, Christian G (2023) Glycoproteomics of a Single Protein: Revealing Tens of Thousands of Myozyme Glycoforms by Hybrid HPLC-MS Approaches. Molecular & cellular proteomics : MCP, 22 (9). p. 100622. ISSN 1535-9484

Dickinson, Michael, Barba, Pere, Jäger, Ulrich, Shah, Nirav N., Blaise, Didier, Briones, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Mariconti, Luisa, Marchal, Anne-Laure, Quinn, David, Yang, Jennifer, Price, Andrew, Sohoni, Akash Kamalakar, Treanor, Louise, Orlando, Elena, Mataraza, Jennifer, Davis, Jaclyn, Lu, Darlene, Xu, Zhu, Engels, Boris, Brogdon, Jennifer, de Parseval, Laure, Moschetta, Michele and Flinn, Ian (2023) A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-Cell Stemness Shows Enhanced CAR T-Cell Efficacy in Preclinical and Early Clinical Development. Cancer discovery. ISSN 2159-8290

Dickinson, Michael, Barba, Pere, Jäger, Ulrich, Shah, Nirav N., Blaise, Didier, Briones, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Mariconti, Luisa, Marchal, Anne-Laure, Quinn, David, Yang, Jennifer, Price, Andrew, Sohoni, Akash Kamalakar, Treanor, Louise, Orlando, Elena, Mataraza, Jennifer, Davis, Jaclyn, Lu, Darlene, Zhu, Xu, Engels, Boris, Brogdon, Jennifer, de Parseval, Laure, Moschetta, Michele and Flinn, Ian (2023) A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-Cell Stemness Shows Enhanced CAR T-Cell Efficacy in Preclinical and Early Clinical Development. Cancer discovery. ISSN 2159-8290

Diegel, Cassandra R., Kramer, Ina, Moes, Charles Gerard, Foxa, Gabrielle E., McDonald, Mitchell J., Madaj, Zachary B., Guth-Gundel, Sabine, Liu, Jun, Harris, Jennifer, Kneissel, Michaela and Williams, Bart O. (2023) Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5. Bone research, 11 (1). pp. 47-59. ISSN 2095-4700

Diegel, Cassandra R., Kramer, Ina, Moes, Charles Gerard, Foxa, Gabrielle E., McDonald, Mitchell J., Madaj, Zachary B., Guth-Gundel, Sabine, Liu, Jun, Harris, Jennifer L., Kneissel, Michaela and Williams, Bart O. (2023) Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5. Bone research, 11 (1). p. 47. ISSN 2095-6231

Ding, Jian, Li, Guo, Liu, Hejun, Liu, Lulu, Lin, Ying, Gao, Jingyan, Zhou, Guoqiang, Shen, Lingling, Zhao, Mengxi, Yu, Yanyan, Guo, Weihui, Hommel, Ulrich, Ottl, Johannes, Blank, Jutta, Aubin, Nicola, Wei, Yi, He, Hu, Sage, David, Atadja, Peter, Li, En, Jain, Rishi, Tallarico, John, Canham, Steve, Chiang, Yingling and Wang, He (2023) Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chemical Biology. ISSN 1554-89291554-8937

Dittrich, Birger, Connor, Lauren, Werthmueller, Dominic, Sykes, Nicole and Udvarhelyi, Aniko (2023) Energy partitioning of pharmaceutical cocrystal structures. Cryst. Eng. Comm..

Dodge, Robert (2023) Neutralizing Antibody Validation Testing and Reporting Harmonization. The AAPS journal, 25 (4). p. 69. ISSN 1550-7416

Dunger-Baldauf, Cornelia, Hemmings, Rob, Bretz, Frank, Jones, Byron, Schiel, Anja and Holmes, Chris (2023) Generating the Right Evidence at the Right Time: Principles of a New Class of Flexible Augmented Clinical Trial Designs. Clinical pharmacology and therapeutics, 113 (5). pp. 1132-1138. ISSN 1532-6535

Dörner, Thomas, Kaul, Martin, Szántó, Antónia, Jui-Cheng, Tseng, Papas, Athena, Pylvaenaeinen, Ilona, Hanser, Malika, Abdallah, Nasri, Grioni, Andrea, Santos da Costa, Aida, Ferrero, Enrico, Gergely, Peter, Hillenbrand, Rainer, Avrameas, Alexandre, Cenni, Bruno and Siegel, Richard (2023) Efficacy and safety of remibrutinib, a selective, potent oral BTK inhibitor, in Sjögren’s syndrome. Annals of Rheumatic Diseases.

E

Emilsson, Valur, Jonsson, GB, Jennings, Lori and Gudnason, Vilmundur (2023) Proteomic prediction of incident heart failure and its main subtypes. European journal of heart failure. ISSN 1879-0844

Erdemli, Gul, Curcic, Jelena, Brem, Anna-Katherine, Kuruppu, Sajini, de Boer, Casper, Muurling, Marijn, Diaz-Ponce, Ana, Gove, Dianne, Pilotto, Andrea, Ng, Wan-Fai, Cummins, Nicholas, Malzbender, Kristina, Nies, Vera J. M., Graeber, Johanna, Narayan, Vaibhav A., Maetzler, Walter, Rochester17,18, Lynn and Aarsland, Dag (2023) Digital endpoints in clinical trials of Alzheimer’s disease and other neurodegenerative diseases: challenges and opportunities. Frontiers in Neurology, 14. ISSN 1664-2295

Ertl, Peter, Altmann, Eva and Racine, Sophie (2023) The most common linkers in bioactive molecules and their bioisosteric replacement network. Bioorganic & medicinal chemistry, 81. p. 117194. ISSN 1464-3391

Ertl, Peter, Altmann, Eva, Racine, Sophie and Decoret, Odile (2023) Which boronic acids are used most frequently for synthesis of bioactive molecules? Bioorganic & medicinal chemistry, 91. p. 117405. ISSN 1464-3391

F

Fairchild, Lauren, Whalen, Jeanne, D'Aco, Katie, Wu, Jincheng, Gustafson, Ben, Su, Fei, Leary, Rebecca, Campbell, Katie and Balbin, Oscar (2023) Clonal hematopoiesis detection in patients with cancer using cell-free DNA sequencing. Science translational medicine, 15 (689). ISSN 1946-6242

Firaha, Dzmitry, Liu, Yifei Michelle, van de Streek, Jacco, Sasikumar, Kiran, Dietrich, Hanno, Helfferich, Julian, Aerts, Luc, Braun, Doris E., Broo, Anders, DiPasquale, Antonio G., Lee, Alfred Y., Le Meur, Sarah, Nilsson Lill, Sten O., Lunsmann, Walter J., Mattei, Alessandra, Muglia, Pierandrea, Putra, Okky Dwichandra, Raoui, Mohamed, Reutzel-Edens, Susan, Rome, Sandrine, Sheikh, Ahmad Y., Tkatchenko, Alexandre, Woollam, Grahame and Neumann, Marcus A. (2023) Predicting crystal form stability under real-world conditions. Nature (623). pp. 324-328. ISSN s41586-023-06587-3

Flynn, Julia, Huang, Qui Yu, Zvornicanin, Sarah, Schneider-Nachum, Gily, Shaqra, Ala, Kurt Yilmaz, Nese, Moquin, Stephanie, Dovala, Dustin, Schiffer, Celia and Bolon, Daniel (2023) Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. ACS infectious diseases, 9 (7). pp. 1372-1386. ISSN 2373-8227

Forte, Nafsika, Dovala, Dustin, Hesse, Matthew, McKenna, Jeffrey, Tallarico, John, Schirle, Markus and Nomura, Daniel (2023) Targeted Protein Degradation through E2 Recruitment. ACS chemical biology, 18 (4). pp. 897-904. ISSN 1554-8937

G

Gallou, Fabrice (2023) Alternative synthesis of 5-(1H-Pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridazin-3-yl}phenol. Helvetica Chimica Acta, 106 (3). e202200186.

Gallou, Fabrice (2023) Biocatalysis in water or in non-conventional media? Adding the CO2 production for the debate. Molecules, 28 (18). p. 6452.

Gallou, Fabrice (2023) Does the Red Shift in UV-Vis Spectra Really Provide a Sensing Option for Detection of N-nitrosamines Using Metalloporphyrins? ACS omega, 8 (1). pp. 1154-1167.

Gallou, Fabrice (2023) Ligand-Free Regioselective Aromatic Hydrogenation of Phosphine Oxide Scaffolds: An Easy Access to New Phosphine Ligands. Angewandte Chemie. International edition, 2023. ISSN 1521-3773; 0570-0833; 1433-7851

Gallou, Fabrice (2023) Micellar Catalysis as a Tool for Suzuki-Miyaura Cross-Couplings in Water. Helvetica chimica acta, 106 (11). e202300143.

Gallou, Fabrice (2023) Palladium-catalyzed micellar cross-couplings : An Outlook. Coordination Chemistry Reviews, 488 (1). p. 215158.

Gallou, Fabrice (2023) Recent progress in Sonogashira-Hagihara cross-couplings in water. Chem Catalysis, 3 (1). p. 100485.

Gallou, Fabrice (2023) Recent progress in water-based Sonogashira cross-couplings in water. Chem Catalysis, 3 (1). 100485,. ISSN 2667-1093

Gallou, Fabrice (2023) Status check: Chemocatalysis & Biocatalysis = Chemoenzymatic Catalysis. Let’s Just Call it “Catalysis”…from the eyes of the fine chemical industry. Green Chemistry, 25. pp. 6092-6107.

Gallou, Fabrice (2023) Surfactant + water: efficient solution to trigger undirected & mild C–H activation of (oligo)thiophenes at challenging β-position. Angewandte Chemie. International edition, 14. pp. 12049-12055.

Gallou, Fabrice (2023) Sustainable cascade water reaction combining transition metal-biocatalysis and hydrophobic substrates: The effect of solvent structuring. Chemical Journal of Engineering, 472. p. 144599.

Gallou, Fabrice (2023) "Where chemocatalysis meets biocatalysis ... in water. Nature–ally!". Chemical reviews.

Gervais, Annick, Pohl, Thomas, Dirksen, Eef, Bechtold-Peters, Karoline, Burkitt, Will, D'Alessio, Valerio, Lennard, Andrew, Li, Xue, Lössner, Christopher, Niu, Ben, Reusch, Dietmar, O'Riordan, Tomas, Shearer, Justin, Spencer, David, Wei, Xu and Yi, Linda (2023) Compliance and regulatory considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 191. pp. 57-67. ISSN 1873-3441

Gimeno, Ramon, Ribas-Llaurado, Clara, Pesque, David, Andrades, Evelyn, Cenni, Bruno, Ambros, Barbara, Pujol, Ramon and Gimenez-Arnau, Ana Maria (2023) Remibrutinib inhibits hives effector cells stimulated by serum from chronic urticaria patients independently of FcεR1 expression level and omalizumab clinical response. Clinical and Translational Allergy, 13 (3). ISSN 2045-70222045-7022

Glowienke, Susanne (2023) Acceptable Intakes (AIs) for 11 Simple N-Nitrosamine (NA) Impurities. Regulatory toxicology and pharmacology.

Glowienke, Susanne (2023) Assessing the utility of common arguments used in expert review of in silico predictions as part of ICH M7 assessments. Regulatory toxicology and pharmacology.

Glowienke, Susanne (2023) Data sharing for aromatic amines. Vitic aromatic amine.

Goetz, J., Jackl, M. K., Jindakun, C., Marziale, A. N., Andre, Jerome, Gosling, Daniel, Springer, C., Palmieri, Marco, Reck, Marcel, Luneau, Alexandre, Brocklehurst, Cara and Bode, J. W. (2023) High-throughput synthesis provides data for predicting molecular properties and reaction success. Science advances, 9 (43). eadj2314. ISSN 2375-2548

Gold, Sarah (2023) Workshadowing final presentation. N/A, N/A (N/A). N/A-N/A. ISSN N/A

Golden, Emily, Amberg, Alexander, Anger, Lennart T, Baker, Elizabeth, Baran, Szczepan W, Bringezu, Frank, Clark, Matthew, Duchateau-Nguyen, Guillemette, Escher, Sylvia E, Giri, Varun, Grevot, Armelle, Hartung, Thomas, Li, Dean Dingzhou, Muster, Wolfgang, Snyder, Kevin, Wange, Ronald and Steger-Hartmann, Thomas (2023) Towards implementing virtual control groups in nonclinical safety studies: Workshop report and roadmap to implementation. ALTEX.

Granberg, Arzu (2023) People of TM: Video of Arzu Granberg. LinkedIn.

Grandeury, Arnaud, De Caro, Liberato, Del Giudice, Alessandra, Giannini, Cinzia, Gozzo, Fabia, Morin, Mickael and Reinle-Schmitt, Mathilde (2023) Small Angle X-ray Scattering data analysis and theoretical modelling for the size and shape characterization of drug delivery systems based on Vitamin E TPGS micelles. Journal of pharmaceutical sciences, 112 (1). pp. 243-249. ISSN 10.1016/j.xphs.2022.09.029

Grandjean, Joanes, Doelemeyer, Arno, Zurbruegg, Stefan and Beckmann, Nicolau (2023) A consensus protocol for functional connectivity analysis in the rat brain. Nature neuroscience. ISSN 1546-1726; 1097-6256

Gray, Audrey, Bonazzi, Simone, Craig, Lucas, Capre, Ketthsy, Lubicka, Danuta, Curtis, Daniel, McTighe, Stephanie, Wilson, Christopher, Burdette, Doug, Dhamne, Sameer, Modi, Meera, Bainbridge, Elizabeth, Lalani, Lahin, Super, Chloe, Schaeffer, Samantha, Gurnani, Sarika, Vermudez, Sheryl Anne D, Hameed, Mustafa, D'Amore, Angelica, Rotenberg, Alexander and Sahin, Mustafa (2023) Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor. Annals of clinical and translational neurology. ISSN 2328-9503

Gusev, Arkady, Mikhailov, Dmitri, Loureiro, Joe, Patel, Michael, Lee, Dana and Rapp, Charles (2023) Decentralized clinical trial design using blood microsampling technology for serum bioanalysis. Bioanalysis, 15 (21). pp. 1287-1303. ISSN 1757-6199

H

Hartout, Philip, Pocuca, Bojana, Mendez Garcia, Celia and Schleberger, Christian (2023) Investigating the human and nonobese diabetic mouse MHC class II immunopeptidome using protein language modeling. Bioinformatics (Oxford, England), 39 (8). ISSN 1367-4811

Harwood, Matthew D, Zettl, Katharina, Weinheimer, Manuel, Pilla-Reddy, Venkatesh, Shen, Hong, Jacobs, Frank, Chu, Xiaoyan, Huth, Felix, Nakakariya, Masanori, Chothe, Paresh, Neuhoff, Sibylle and Wisniewski, Jacek R (2023) Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome. Molecular pharmaceutics. ISSN 1543-8392

Hassanein, Mohamed, Qiu, Iris, Zeng, Jianing and Hays, Amanda (2023) Drug Development Through the Prism of Biomarkers: Current State and Future Outlook. AAPS News Magazine.

Hawtin, Stuart, Andre, Cedric Bernard, Collignon Zipfel, Geraldine, Appenzeller, Simone, Bettina, Bannert, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Hermine, Brunner, Ceci, Melanie, Jonathan, Deane, Feifel, Roland, Ferrero, Enrico, Diego, Kyburz, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Pierre, Michellys, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, James, Rush, Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas and Junt, Tobias (2023) Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy. Cell reports. Medicine, 4 (5). p. 101036. ISSN 2666-3791

Heim, Sabina (2023) Zebrafish for drug discovery. Ascenion´s annual report 2021/22.

Heyndrickx, Wouter, Mervin, Lewis, Morawietz, Tobias, Sturm, Noe, Friedrich, Lukas, Zalewski, Adam, Pentina, Anastasia, Humbeck, Lina, Oldenhof, Martijn, Niwayama, Ritsuya, Schmidtke, Peter, Fechner, Nikolas, Simm, Jaak, Arany, Adam, Drizard, Nicolas, Jabal, Rama, Afanasyeva, Arina, Loeb, Regis, Verma, Shlok, Harnqvist, Simon, Holmes, Matthew, Pejo, Balazs, Telenczuk, Maria, Rieke, Nicola, Holway, Nicholas, Dieckmann, Arne, Zumsande, Friederike, Clevert, Djork-Arné, Krug, Michael, Luscombe, Christopher, Green, Darren, Ertl, Peter, Antal, Peter, Marcus, David, Do Huu, Nicolas, Fuji, Hideyoshi, Pickett, Stephen, Acs, Gergely, Boniface, Eric, Beck, Bernd, Sun, Yax, Gohier, Arnaud, Rippmann, Friedrich, Engkvist, Ola, Goeller, Andreas H., Moreau, Yves, Galtier, Mathieu, Schuffenhauer, Ansgar and Ceulemans, Hugo (2023) MELLODDY: Cross-pharma Federated Learning at Unprecedented Scale Unlocks Benefits in QSAR without Compromising Proprietary Information. Journal of chemical information and modeling. ISSN 1549-960X

Hien, Hsiaotzu, Prior, Helen, Andrews, Laura, Van Aerts, Leon, Cauvin, Annick, Clarke, David O., Datta, Kaushik, Dempster, Maggie, Dybdal, Noel, Freebern, Wendy, de Hann, Lolke, Herzyk, Danuta, Hey, Adam, Kissner, Thomas, Kronenberg, Sven, Leach, Michael W., Lee, Donna, Schutte, Karin, Sewell, Fiona, Trouba, Kevin, Ulrich, Peter, Weir, Lucinda and van Meer, Peter (2023) Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach. Regulatory Toxicology and Pharmacology, 138.

Hoch, Matthias, Bebrevska, Lidiya, Singh, Namrata and Hourcade-Potelleret, Florence (2023) Relative Bioavailability and Food Effect of Asciminib Pediatric Mini-tablet Formulation Compared to the Reference Tablet Formulation in Healthy Adult Participants. Clinical Pharmacology in Drug Development.

Hochberg, Natasha, Rao, Srinivasa, Angyalosi, Gerhild, Zhao, Xiaojun, Carballo, Leticia, Demacq Souza Tarla, CAROLINE, Braud-Perez, Sofia, Wieser, Daniela, Casas Romero, JP, Millholland, John and Ngo, Debby (2023) An end is in sight: A perspective on PCR as an endpoint for Chagas disease treatment trials. Frontiers in Parasitology, 2. ISSN 2813-2424

Huppertz, Christine, Boutouyrie-Dumont, Bruno, Behrens, Frank, FitzGerald, Oliver, Barton, Ann, Bertheussen, Heidi, Davies, Owen, Coates, Laura, de Wit, Maarten, Fagni, Filippo, Goodyear, Carl, Gurke, Robert, Hahnfeld, Lisa, Ioannidis, Vassilios, Ibberson, Mark, Katz, Arnon, Klippstein, Maximilian, Koehm, Michaela, Korish, Shimon, Patel, Khadijah, Mackay, Sina, Martin, David, O Sullivan, Denis, Rüping, Stefan, Schett, Georg, Scholich, Klaus, Schwenk, Jochen, Siebert, Stefan, Simon, David, Vivekakantham, Arani and Pennington, Stephen (2023) Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis. Therapeutic advances in musculoskeletal disease, 15. 1759720X-231192315. ISSN 1759-720X

I

Ispasanie, Emma, Muri, Lukas, Schmid, Marc, Schubart Wellensiek, Anna, Thorburn, Christine, Zamurovic Ribrioux, Natasa, Holbro, Thomas, Kammueller, Michael and Pluschke, Gerd (2023) In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway. Frontiers in immunology, 14. ISSN 1664-3224

Isshiki, Takuma, Vierhout, Megan, Naiel, Safaa, Yazdanshenas, Parichehr, Kumaran, Vaishnavi, Ali, Pareesa, Yang, Zi, Dvorkin-Gheva, Anna, Rullo, Anthony F, Kolb, Martin and Ask, Kjetil (2023) Therapeutic strategies targeting pro-fibrotic macrophages in interstitial lung disease. Biochemical pharmacology. p. 115501. ISSN 1873-2968

Itskanov, Samuel, Wang, Laurie, Junne, Tina, Sheriff, Rumi, Blanchard, Nicolas, Shi, Wei, Forsyth, Craig, Hoepfner, Dominic, Spiess, Martin and Park, Eunyong (2023) A common mechanism of Sec61 translocon inhibition by small molecules. Nature chemical biology. ISSN 1552-4469

J

James, Alexander David, Kulmatycki, Ken, Poller, Birk, Romeo, Andrea, Van Lier, Jan Jaap, Klein, Kai and Pearson, David (2023) Absorption, Distribution, Metabolism, and Excretion of [14C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies. Drug metabolism and disposition: the biological fate of chemicals, 51 (7). pp. 873-883. ISSN 1521-009X

Jelsch, Morgane, Roggo, Yves, Brewer, Mark, Géczia, Zsolt-Adam, Heger, Philipp, Kleinebudde, Peter and Krumme, Markus (2023) Advanced process automation of a pharmaceutical continuous wet granulation line: Model Predictive Control from solid feeders to dryer. Powder technology, 429. ISSN 00325910

Ji, Yan, Calonder, Claudio, Kirsilae, Tiina, Joubert, Yolandi, Laurent, Nathalie, Hua, Eva, Patekar, Manmath, Drollmann, Anton Franz and Woessner, Ralph (2023) Comprehensive Assessment of Pharmacokinetics, Pharmacodynamics, and Tolerability of Ligelizumab in Healthy Volunteers and Patients with Chronic Spontaneous Urticaria to Optimize Its Subcutaneous Delivery System. Pharmaceutics, 15 (9). ISSN 1999-4923

Ji, Yan, Calonder, Claudio, Kirsilae, Tiina, Joubert, Yolandi, Laurent, Nathalie, Hua, Eva, Patekar, Manmath, Drollmann, Anton Franz and Woessner, Ralph (2023) Comprehensive assessment of pharmacokinetics, pharmacodynamics and tolerability of ligelizumab in healthy volunteers and patients with chronic spontaneous urticaria to optimize its subcutaneous delivery system. Pharmaceutics, 15 (9). p. 2266. ISSN 1999-4923

Ji, Yan, Darstein, Christelle, Yang, Shu, Quinlan, Michelle, Chakravartty, Arunava, Zarate, Juan Pablo, Chakraborty, Abhijit and Ho, Yu-Yun (2023) Quantitative Assessment of Ribociclib Exposure-Response Relationship to Justify Dose Regimen in Patients with Advanced Breast Cancer. Journal of clinical pharmacology. ISSN 1552-4604

Ji, Yan, Madrasi, Kumpal, Knee, Deborah, Gruenbaum, Lore, Apgar, Joshua, Burke, John and Gomes, Bruce (2023) Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment. CPT: pharmacometrics & systems pharmacology, 12 (3). pp. 413-424. ISSN 2163-8306

Ji, Yan, Madrasi, Kumpal, Knee, Deborah, Gruenbaum, Lore, Apgar, Joshua, Burke, John and Gomes, Bruce (2023) Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment. CPT: pharmacometrics & systems pharmacology, 12 (3). pp. 413-424. ISSN 2163-8306

Ji, Yan, Tan, Eugene, Hengelage, Thomas, Quinlan, Michelle and Hendriks, Bart (2023) Exploratory Food Effect Assessment in Patients in Early Clinical Development of Oncology Drugs. Clinical pharmacology and therapeutics, 114 (2). pp. 288-302. ISSN 1532-6535

Ji, Yan, Tan, Eugene, Hengelage, Thomas, Quinlan, Michelle and Hendriks, Bart (2023) Roadmap for exploratory food effect assessment in early clinical development for oncology drugs - literature and Novartis experience. Clinical pharmacology and therapeutics.

Ji, Yan, Yartsev, Vitaly, Quinlan, Michelle, Serra, Paolo, Wang, Yingbo, Chakraborty, Abhijit and Miller, Michelle (2023) Justifying Ribociclib Dose in Patients with Advanced Breast Cancer with Renal Impairment Based on PK, Safety, and Efficacy Data: An Innovative Approach Integrating Data from a Dedicated Renal Impairment Study and Oncology Clinical Trials. Clinical pharmacokinetics, 62 (3). pp. 493-504. ISSN 1179-1926

Ji, Yan, Yartsev, Vitaly, Quinlan, Michelle, Serra, Paolo, Wang, Yingbo, Chakraborty, Abhijit and Miller, Michelle (2023) Ribociclib Dose Justification in Advanced Breast Cancer Patients With Renal Impairment by Integrating PK, Safety and Efficacy Data. Clinical pharmacokinetics.

Johnson, Eric, Sutherland, Jeffrey, Meseck, Emily, McElroy, Cameron, Chand, Deepa, Tukov, Francis, Hudry, Eloise and Penraat, Kelley (2023) Neurofilament Light Chain and Dorsal Root Ganglia Injury After Adeno-Associated Virus 9 Gene Therapy in Nonhuman Primates. Molecular therapy: Methods and Clinical Development, 28. pp. 208-219. ISSN 2329-0501

Johnson, Eric, Sutherland, Jeffrey, Meseck, Emily, McElroy, Cameron, Chand, Deepa, Tukov, Francis, Hudry, Eloise and Penraat, Kelley (2023) Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates. Molecular therapy. Methods & clinical development, 28. pp. 208-219. ISSN 2329-0501

Jonmundsson, Thorarinn, Jennings, Lori, Gudnason, Vilmundur and Gudmundsdottir, Valborg (2023) A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study). Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 25 (11). ISSN 1532-2092

Jonsdottir, Maria, K., Harrison, John and Hannesdottir, Kristin (2023) The ambivalence towards neuropsychology in dementia research, diagnosis, and drug development: Myths and misconceptions. Alzheimer's & dementia, 19 (5). pp. 2175-2181.

K

Kalamakis, Georgios and Platt, Randall J. (2023) CRISPR for neuroscientists. Neuron. ISSN 08966273

Kanji, Comfort Ropafadzo, Nyabadza, Georgina, Nhachi, Charles and Masimirembwa, Collen (2023) Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen. Journal of personalized medicine, 13 (2). ISSN 2075-4426

Kastrati, Agonist, Kremsmair, Alexander, Sunagatullina, Alisa S., Korotenko, Vasilii, Guersov, Yusuf C., Hess, Andreas, Rout, Saroj. K., Lima, Fabio, Brocklehurst, Cara, Karaghiosoff, Konstantin, Zipse, Hendrik and Knochel, Paul (2023) Calculation-Driven Regioselective Functionalization of the Imidazo[1,2-a]pyrazine Scaffold via Zinc and Magnesium Organometallic Intermediates. Chemical Science. ISSN 2041-65202041-6539

Keuper-Navis, Marit, Walles, Markus, Poller, Birk, Myszczyszy, Adan, Van der Made, Thom, Donkers, Joanne, Eslami Amirabadi, Hossein, Wilmer, Martijn, Spee, Bart, Masereeuw, Rosalinde and Van de Steeg, Eviata (2023) The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development. Pharmacological research. p. 106853. ISSN 1096-1186

Kikuchi, Ryota, Chothe, Paresh, Chu, Xiaoyan, Huth, Felix, Ishida, Kazuya, Ishiguro, Naoki, Jiang, Rosa, Shen, Hong, Stahl, Simone, Varma, Manthena, Willemin, Marie-Emilie and Morse, Bridget (2023) Use of Endogenous Biomarkers to Guide OATP1B Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry. Clinical Pharmacology & Therapeutics. ISSN 0009-92361532-6535

King, Elizabeth A., Cho, Yoojin, Dovala, Dustin, McKenna, Jeffrey, Tallarico, John, Schirle, Markus and Nomura, Daniel K. (2023) Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell chemical biology, 30 (4). 394-402.e9. ISSN 2451-9448

Konstantini, Christina, Spilioti, Evanthia, Bevernage, Jan, Ceulemans, Jens, Hansmann, Simone, Hellemans, Katleen, Jede, Christian, Kourentas, Alexandros, Reggane, Maude, Shah, Lipa, Wagner, Christian, Vertzoni, Maria and Reppas, Christos (2023) Screening for Differences in Early Exposure in the Fasted State with in Vitro Methodologies can be Challenging: Experience with the BioGIT System. Journal of pharmaceutical sciences. ISSN 1520-6017

Kostantini, Christina, Spilioti, Evanthia, Bevernage, Jan, Ceulemans, Jens, Hansmann, Simone, Hellemans, Katleen, Jede3, Christian, Kourentas, Alexandros, Reggane, Maude, Shah, Lipa, Wagner, Christian, Reppas, Christos and Vertzoni, Maria (2023) Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis. International journal of pharmaceutics. ISSN 03785173

Kotoni, Dorina, Zelesky, Todd, Foti, Chris and Baertschi, Steve (2023) Pharmaceutical Forced Degradation (Stress Testing) Endpoints: A Scientific Rationale and Industry Perspective. Journal of pharmaceutical sciences, 112 (12). pp. 2948-2964. ISSN 1520-6017

Kourentas, Alexandros, Gajewska, Monika, Dhareshwar, Sundeep, Steib-Lauer, Caroline, Kulkarni, Swarupa, Hirsch, Stefan, Mueller-Zsigmondy, Martin, Wen, Lin and Tycho, Heimbach (2023) Establishing the clinical bioequivalence safe space via physiologically-based population pharmacokinetics absorption modeling. Case study: Fevipiprant/QAW039. Establishing the clinical bioequivalence safe space via physiologically-based population pharmacokinetics absorption modeling. Case study: Fevipiprant/QAW039, 25 ((1)). ISSN DOI: 10.1208/s12248-023-00787-5

Krueger, James G, Langley, Richard G, Nigen, Simon, Kasparek, Torben, Di Comite, Gabriele, Ortmann, Christine-Elke, Garcet, Sandra, Kolbinger, Frank and Reich, Kristian (2023) Secukinumab versus guselkumab in the complete resolution of ustekinumab-resistant psoriatic plaques: The ARROW study. Experimental dermatology, 32 (10). pp. 1834-1847.

Kuzman, Drago, Grum, Eva, Klančnik, Urška and Derganc, Jure (2023) Real-Time Assessment of the Size Changes of Individual Sub-Visible Protein Particles under Buffer Variations: A Microfluidic Study. Pharmaceuticals (Basel, Switzerland), 16 (7). ISSN 1424-8247

L

LaDuke, Carrie, Boulay, Emmanuel, Miraucourt, Lois S., Pugsley, Michael K., Abernathy, Matthew M., Chui, Ray, Dalton, Jill, Demers, Marjorie, Dybdal, Noel, Gazaille, Elissa, Greiter-Wilke, Andrea, Huang, Hai, Norton, Kevin, Pierson, Jennifer B., Reeves, Isabelle, Roche, Brian, Rossman, Eric I., Schultze, Albert E., Tang, Hai-Ming, Wisialowski, Todd and Authier, Simon (2023) The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis. Journal of pharmacological and toxicological methods, 121. p. 107266. ISSN 1873-488X

LaFollette, Megan R, Cloutier, Sylvie, Brady, Colleen M, O'Haire, Marguerite E and Gaskill, Brianna N (2023) Benchmarking Enrichment Efforts in the US & Canada Across Species and Enrichment Categories. Journal of the American Association for Laboratory Animal Science, 62 (4). pp. 1-14. ISSN 1559-6109

Lanshoeft, Christian, Schütz, Raphael, Lozac'h, Frederic, Schlotterbeck, Götz and Walles, Markus (2023) Potential of measured relative shifts in collision cross section values for biotransformation studies. Analytical and Bioanalytical Chemistry. ISSN 1618-2650

Ledermann, Birgit (2023) Interpharma Animal Welfare Report 2023. Interpharma Animal Welfare Report 2023, 2023 (n.a.). n.a.-n.a.. ISSN n.a.

Lehermayr, Christian, Schmelzer, Bernhard and Kropf, Maximilian (2023) Closed System Transfer Devices (CSTDs): understanding potential over- and under- dosing of liquid vial drug products and how to generally mitigate. Journal of pharmaceutical sciences. ISSN 1520-6017

Lehermayr, Christian, Schmelzer, Bernhard and Kropf, Maximilian (2023) Closed System Transfer Devices (CSTDs): understanding potential over- and under- dosing of liquid vial drug products and how to generally mitigate. Journal of pharmaceutical sciences. ISSN 1520-6017

Levin, Itai, Fortunato, Mike, Tan, Kian and Coley, Connor (2023) Computer-aided evaluation and exploration of chemical spaces constrained by reaction pathways. AIChE journal.

Lewis, Richard, Isert, Clemens, Kromann, Jimmy, Stiefl, Nikolaus and Schneider, Gisbert (2023) Machine intelligence models for fast, quantum mechanics-based approximation of drug lipophilicity. ACS Omega. ISSN 2470-13432470-1343

Li, Wei and Leclair, Alexandre (2023) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic process research & development, 27 (11). pp. 1858-1867. ISSN 1520-586X

Li, Wei and Steven, Alan (2023) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development, 27 (4). pp. 563-570. ISSN 1083-61601520-586X

Li, Wenkui, Vazvaei-Smith, Faye, Dear, Gordon, Boer, Jason, Cuyckens, Filip, Fraier, Daniela, Liang, Yuexia, Lu, Ding, Mangus, Heidi, Moliner, Patricia, Pedersen, Mette L., Romeo, Andrea A., Spracklin, Douglas K., Wagner, David S., Winter, Serge and Xu, Xiaohui (Sophia) (2023) Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group. Clinical Pharmacology & Therapeutics. ISSN 0009-92361532-6535

Li, Yao, Slavik, Kailey, Morehouse, Benjamin, de Oliveria Mann, Carina, Mears, Kepler, Liu, Jingjing, Intemann, Andrea, Schwede, Frank and Kranzusch, Philip (2023) cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186 (15). 3261-3276.e20. ISSN 1097-4172

Linden, Anthony, Bucher, Christoph, Gubler, Ralf, Villalgordo, José M. and Heimgartner, Heinz (2023) Synthesis and crystal structures of new chiral 3-amino-2H-azirines and the Pd complex of one of them. Acta crystallographica. Section C, Structural chemistry, 79 (Pt 3). pp. 104-111. ISSN 2053-2296

Lindenberg, Christian, Abarrou, Nounja, DeCollibus, Daniel, Searcy, Justin, Tivesten, Anna, Akhtar, Nadim, Pradhan, Sujana, Fiandaca, Maggie, Franklin, Jenny, Govindan, Geetha, Hung-Yi, Liu, Royle, David, Lim Soo, Patrick and Storch, Kirsten (2023) Considerations for the Terminal Sterilisation of Oligonucleotide Drug Products. Nucleic Acid Therapeutics. ISSN 2159-33372159-3345

Linker, Stephanie M., Schellhaas, Christian, Kamenik, Anna S., Riniker, Sereina, Roth, Hans-Joerg, Fouche, Marianne and Rodde, Stephane (2023) Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes. Journal of medicinal chemistry, 66 (4). pp. 2773-2788. ISSN 1520-4804

Liu, Lulu, Fang, Yanjia, Ding, Xiaodan, Zhou, Weihua, Terranova, Remi, Zhang, Yan and Wang, He (2023) Wdr5 is essential for fetal erythropoiesis and hematopoiesis. Experimental hematology & oncology, 12 (1). p. 39. ISSN 2162-3619

Liu, Lulu, Guo, Xin, Wang, Vickie, Li, Melody, Yu, Yanyan, Song, Yang, Zeng, Chenhui, Ding, Zhilou, Qiu, Yuanjun, Yan, Feifei, Zhang, Yixiang, Zhao, Caiqi, Zhang, Yan, Dou, Yali, Atadja, Peter, Li, En and Wang, He (2023) Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets. Biochimica et biophysica acta (BBA) - Molecular basis of disease, 1869 (2). p. 166600. ISSN 09254439

Liu, Lulu, Shen, Lingling, Ding, Zhilou, He, Miao, Li, En, Tallarico, John, Jain, Rishi and Wang, He (2023) Mechanism of Resistance to the WDR5 Inhibitor in MLL-Rearranged Leukemia. ACS chemical biology. ISSN 1554-8937

Liu, Samantha Y., Mulugeta, Naomi, Dougan, Stephanie K. and Qiang, Li (2023) In vitro flow cytometry assay to assess human and mouse macrophage phagocytosis of tumor cells. Cell. ISSN 1097-4172; 0092-8674

Luo, Zhu, Huang, zhijun, Sun, Feng, Guo, Fang, Wang, Yingying, Kao, Sheena, Yang, Guoping, Huang, Jie, Li, Jiaxin, Zhao, Sylvia and He, YanLing (2023) The clinical effects of inclisiran, a first-in-class LDL-C lowering siRNA therapy, on the LDL-C levels in Chinese patients with hypercholesterolemia. Journal of clinical lipidology, 17 (3). pp. 392-400. ISSN 1933-2874

M

M. Huelsmeyer, Martin, Kuzman, Drago, Boncina, Matjaz, J. Martinez, J, C. Steinbrugger, C, J. Weusten, J, Calero-Rubio, C, W. Roche, W, B. Niederhaus, B, Y. VanHaelst, Y, M. Hrynyk, M, H. Achard, H, S. Augusto, S, M. Guillois, M, C. Pszczolinski, C, M. Gerasimov, M, C. Neyra, C, D. Ponduri, D, S. Ramesh, S and D. Clénet, Diddier (2023) A universal tool for stability predictions of biotherapeutics, vaccines and in vitro diagnostic products. Scientific reports, 13 (1). p. 10077. ISSN 2045-2322

Makris, Susan L., Beyer, Bruce B., DeLise, Anthony, Williams, Amy L., Roberts, Linda G., Hardy, Janet R., Robinson, Joshua F. and Feldkamp, Marcia L. (2023) Society for Birth Defects Research and Prevention 2022-2027 strategic plan. Birth defects research. pp. 1-4. ISSN 2472-1727

Manjunatha, Ujjini, Diagana, Thierry and Spector, Jonathan (2023) Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease. BMJ global health, 8 (8). ISSN 2059-7908

Marasanapalle, Venugopal, Masimirembwa, Collen, Sivasubramanian, Rama, Sayyed, Sarfaraz Husain, Weinzierl-Hinum, Armin, Mehta, Dheeraj, Kapungu, Nyasha, Kanji, Comfort, Thelingwani, Roslyn and Zack, Julia (2023) Investigation of the differences in the pharmacokinetics of CYP2D6 substrates, desipramine and dextromethorphan in healthy African subjects carrying the allelic variants CYP2D6*17 and CYP2D6*29 when compared with normal metabolizers. The journal of clinical pharmacology.. pp. 1-12. ISSN 1552-4604; 0091-2700

Martinez Ledo, Adriana, Dimke, Thomas, Tschantz, Bill, Rowlands, David and Growcott, Ellena (2023) The role of airway mucus and diseased pulmonary epithelium on the absorption of inhaled antibodies. International journal of pharmaceutics, 647. p. 123519. ISSN 1873-3476

Marulanda, Juliana, Tauer, Josephine, Boraschi-Diaz, Iris, Bardai, Ghalib and Rauch, Frank (2023) Effect of Sclerostin Inactivation in a Mouse Model of Severe Osteogenesis Imperfecta. Scientific reports.

Mascardi, María Florencia, Mazzini, Flavia Noelia, Suárez, Bárbara, Ruda, Vera, Marciano, Sebastián, Casciato, Paola, Narvaez, Adrián, Haddad, Leila, Anders, Margarita, Orozco, Federico, Tamaroff, Ana Jesica, Cook, Frank, Gounarides, John, Gutt, Susana, Gadano, Adrián, Mendez Garcia, Celia, Marro, Martin L., Steinhardt, Alberto Penas and Trinks, Julieta (2023) Integrated analysis of the transcriptome and its interaction with the metabolome in metabolic associated fatty liver disease: Gut microbiome signatures, correlation networks, and effect of PNPLA3 genotype. Proteomics, 23 (18). e2200414. ISSN 1615-9861

Mascardi, María Florencia, Mazzini, Flavia Noelia, Suárez, Bárbara, Ruda, Vera, Marciano, Sebastián, Casciato, Paola, Narvaez, Adrián, Haddad, Leila, Anders, Margarita, Orozco, Federico, Tamaroff, Ana Jesica, Cook, Frank, Gounarides, John, Gutt, Susana, Gadano, Adrián, Mendez Garcia, Celia, Marro, Martin L., Steinhardt, Alberto Penas and Trinks, Julieta (2023) Integrated analysis of the transcriptome and its interaction with the metabolome in metabolic associated fatty liver disease: Gut microbiome signatures, correlation networks, and effect of PNPLA3 genotype. Proteomics, 23 (18). e2200414. ISSN 1615-9861

McBlane, Fraser (2023) PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper. The AAPS journal, 25 (5). p. 78. ISSN 1550-7416

McKenna, Jeffrey, Dovala, Dustin, Frank, Andreas, Hesse, Matthew, Song, Jae, Bruce-Smythe, Megan, Struble, Heidi, Garcia, Francisco, Brittain, Scott, Kile, Drew, McGregor, Lynn, Tallarico, John, Schirle, Markus, Toriki, Ethan, Papatzimas, James, Nishikawa, Kaila, Dankova, Daniela and Nomura, Daniel (2023) Rational Chemical Design of Molecular Glue Degraders. ACS Central Science. ISSN 2374-79432374-7951

McKenna, Jeffrey and Proctor, Rupert (2023) Covalency-enabled Drug Discovery is redefining druggability. Chimia : international journal for chemistry.

Michel, Erich, Cucuzza, Stefano, Mittl, Peer R E, Zerbe, Oliver and Plückthun, Andreas (2023) Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry, 62 (2). pp. 318-329. ISSN 1520-4995

Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene and Zink, Florence (2023) Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. ACS medicinal chemistry letters, 14 (8). pp. 1054-1062. ISSN 1948-5875

Micó-Amigo, Encarna, Bonci, Tecla, Parasichiv-Ionescu, Anisoara, Ullrich, Martin, Kirk, Cameron, Soltani, Abolfazl, Kuederle, Arne, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Phil, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D’Ascanio, Ilaria, Eskofier, Bjoern, Fernstad, Sara, Froehlich, Marcel, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeff, Hiden, Hugo, Hume, David, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison, Rochester, Lynn, Mazzà, Claudia and Del Din, Silva (2023) Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium. Journal of neuroengineering and rehabilitation, 20 (1). p. 78. ISSN 1743-0003

Mitra, Amitava, Lee, Jongbong, Steinbach, Douglas, Hazra, Anasuya and Krishna, Rajesh (2023) Rare oncology therapeutics: review of clinical pharmacology package of drug approvals (2019-2023) by US FDA, best practices and recommendations. Journal of pharmacokinetics and pharmacodynamics. ISSN 1573-8744

Moebitz, Henrik (2023) Design principles for balanced lipophilicity and permeability in beyond Rule of 5 space. ChemMedChem : chemistry enabling drug discovery. ISSN 1860-71791860-7187

Monné Rodríguez, Josep M., Frisk, Anna-Lena, Kreutzer, Robert, Lemarchand, Thomas, Lezmi, Stephane, Saravanan, Chandrassegar, Stierstorfer, Birgit, Thuilliez, Céline, Vezzali, Enrico, Wieczorek, Grazyna, Yun, Seong-Wook and Schaudien, Dirk (2023) European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development. Toxicologic pathology. p. 1926233231178282. ISSN 1533-1601

Morar Mitrica, Sorina, Pohl, Thomas, Theisen, Dietmar, Boll, Björn, Bechtold-Peters, Karoline, Schipflinger, Reinhard, Beyer, Beate, Zierow, Swen, Kammueller, Michael, Pribil, Andreas, Schmelzer, Bernhard, Boehm, Stephan, Goetti, Micheline and Serno, Tim (2023) An Intra-Company Analysis of Inherent Particles in Biologicals Shapes the Protein Particle Mitigation Strategy Across Development Stages. Journal of pharmaceutical sciences. ISSN 00223549

Mueller, Matthias and Fruh, Isabelle (2023) Engineering circuits of human iPSC-derived neurons and rat primary glia. Frontiers in neuroscience, 17. ISSN 1662-4548

Mutlu, Merve, Schmidt, Isabel, Morrison, Andrew, Goretzki, Benedikt, Freuler, Felix, Begue, Damien, Pythoud, Nicolas, Ahrne, Erik, Kapps-Fouthier, Sandra, Roest, Susan, Bonenfant, Debora, Jeanpierre, Delphine, Tran, Thi-Thanh-Thao, Maher, Rob, An, Shaojian, Rietsch, Amandine, Nigsch, Florian, Hofmann, Andreas, Reece-Hoyes, John, Parker, Christian and Guerini, Danilo (2023) A novel HERC4-dependent glue degrader targeting STING. BioRxiv, N/A (N/A). N/A-N/A. ISSN 2692-8205

N

Naga, Doha, Dimitrakopoulou, Smaragda, Roberts, Sonia, Husar, Elisabeth, Mohr, Susanne, Booler, Helen and Musvasva, Eunice (2023) CSL-Tox: An open-source analytical framework for the comparison of short-term and long-term toxicity end points and exploring the opportunities for decreasing in-vivo studies conducted for drug development programs.”. Nature Scientific Reports.

Nettleton, David (2023) Industry Perspective on the Pharmacokinetic and ADME Characterization of Heterobifunctional Protein Degraders. Drug metabolism and disposition, 51 (7). pp. 792-803. ISSN 1521-009X/51/7/792

Newham, Peter, Steger-Hartmann, Thomas, Beilmann, Mario, Dear, Gordon, Valentin, Jean-Pierre, Hewitt, Philip and Pognan, Francois (2023) The evolving role of investigative toxicology in the pharmaceutical industry. Nature reviews drug discovery. ISSN 1474-1784; 1474-1776

Nguyen, Tina, Lau, Anthony, Bier, Julia, Lenthall, Helen, Ruiz-Diaz, Stephanie, Brigden, Henry, Droney, Luke, Okada, Satoshi, Abolhassani, Hassan, Chavoshzadeh, Zarah, Abraham, Roshini, Rajapakse, Nipunie, Klee, Eric W, Church, Joseph A, Williams, Andrew, Wong, Melanie, Burkhart, Christoph, Uzel, Gulbu, Brink, Robert, Tangye, Stuart G and Deenick, Elissa K (2023) Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2. The Journal of Experimental Medicine, 220 (6). ISSN 1540-9538

Nuesslein-Hildesheim, Barbara, Ferrero, Enrico, Schmid, Cindy, Huck, Catherine, Smith, Paul, Tisserand, Sarah, Rubert, Joelle, Bornancin, Frederic, Eichlisberger, Denis and Cenni, Bruno (2023) Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of Multiple Sclerosis. Journal of neuroinflammation, 20. p. 194. ISSN 1742-2094

O

Oberlick, Elaine, Smith, Tomas, Park, Seonmi, Bray, Mark, Antczak, Christophe, Corey, Driscoll, Sarah, Mowbray and Duncan, Nunes (2023) GATA1 deletion in human pluripotent stem cells increases differentiation yield and maturity of neutrophils. iScience, 26 (10). p. 107804. ISSN 2589-0042

Obrecht, Michael, Zurbruegg, Stefan, Accart Gris, Nathalie, Lambert, Christian, Doelemeyer, Arno, Ledermann, Birgit and Beckmann, Nicolau (2023) Imaging in Small Rodents in the Context of Pharmacological Research: Significance of the 3R Principles. Frontiers in pharmacology, 14. p. 1177421. ISSN 10.3389/fphar.2023.1177421

Olaleye, Oladapo, Graf, Christian and Bischoff, Rainer (2023) Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of the American Society for Mass Spectrometry.

Ong, Joseph (2023) Advanced analytical approaches for AAV empty/full Capsid characterAdvanced Analytical Approaches For AAV Empty/Full Capsid Characterization And Quantificationization and quantification. BioProcess Online.

P

Palanisamy, Arnesh, Martinez Heredia, Lizbeth, Adler, Camille and Gururajan, Bindhu (2023) COMPARATIVE ANALYSIS OF POROSITY MEASUREMENT TECHNIQUES USING PHARMACEUTICAL MATERIALS. 10th International Granulation Workshop.

Patel, Mitesh, Riede, Julia, Bednarczyk, Dallas, Poller, Birk and Deshmukh, Sujal (2023) Simplifying the Extended Clearance Concept Classification System (EC3S) to Guide Clearance Prediction in Drug Discovery. Pharmaceutical research. ISSN 1573-904X

Penner, Patrick and Vulpetti, Anna (2023) QM assisted ML for 19F NMR chemical shift prediction. Journal of computer-aided molecular design, 38 (1). p. 4. ISSN 1573-4951

Peukert, Stefan, Gulgeze Efthymiou, Hatice, Mo, Ruowei, Peng, Yunshan, Buono, Chiara, Daniels, Thomas, Zhang, Xia, Adachi, Yuichiro, Taggart, Andrew, Ma, Fupeng, Guillaume, Barbe, Gregory, Bebernitz, Cary, Fridrich, Eric, Williams, Lisha, Li and Mie, Abe (2023) Discovery of a brain sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation. Bioorganic and medicinal chemistry letters, 85 (129237). pp. 1-6. ISSN 0960-894X

Piperno-Neumann, S, Carlino, M, Boni, V, Speetjens, FM, Park, JJ, Calvo, E, Carvajal, RD, Nyakas, M, Gonzalez Maffe, Juan, Zhu, Xu, Shirley, Matt, Ramkumar, Thiruvamoor, Fessehatsion, Adonai, Burks, Heather, Yerramilli-Rao, Padmaja and Kapiteijn, E (2023) A phase I trial of LXS196, a protein kinase C (PKC) inhibitor, for metastatic uveal melanoma. British journal of cancer. ISSN 1532-1827

Pistorius, Dominik, Buntin, Kathrin, Richard, Etienne, Rust, Michael, Bouquet, Caroline, Wollbrett, Severine, Weber, Eric, Dietschin, Daniele, Bruccoleri, Robert, Oakeley, Edward James and Petersen, Frank (2023) Valhidepsin Lipopeptides from Chromobacterium vaccinii: Structures, Biosynthesis, and Coregulation with FR900359 Production. Journal of natural products. ISSN 1520-6025

Pogodaev, Alex, Hernandez Rodriguez, Tanja Nadine, LI, Mengyao and Garcia Munzer, David Gerardo (2023) Modeling of bioprocess pre-stages for optimization of perfusion profiles and increased process understanding. Biotechnology and bioengineering. ISSN 1097-0290

Pohl, Thomas, Gervais, Annick, Dierksen, Eef, D'Alessio, Valerio, Bechtold-Peters, Karoline, Burkitt, Will, Cao, Li, Greven, Simone, Lennard, Andrew, Li, Xue, Lössner, Christopher, Niu, Ben, Reusch, Dietmar, O'Riordan, Tomas, Shearer, Justin, Spencer, David, Xu, Wei and Yi, Linda (2023) Technical considerations for the implementation of the Multi-Attribute-Method by mass spectrometry in a Quality Control laboratory. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 188. pp. 231-242. ISSN 1873-3441

Polak, Jakub, von Stosch, Moritz, Sokolov, Michael, Piccioni, Lorenzo, Streit, Alexander, Schenkel, Berthold and Guelat, Bertrand (2023) Hybrid modeling supported development of an industrial small-molecule flow chemistry process. Computers & chemical engineering, 170. ISSN 00981354

Poloni, Lorenzo, Lubej, Martin, Palanisamy, Arnesh and Gururajan, Bindhu (2023) INDUSTRIAL CASE STUDY ON APPLICATION OF ROLLER COMPACTION MODELLING FOR SCALE UP AND TECHNOLOGY TRANSFER. Pharmaceutical research.

Prahallad, Anirudh, Weiss, Andreas, Voshol, Johannes, Kerr, Grainne, Yuan, Tina, Ruddy, David, Meistertzheim, Morgane, Kazic-Legueux, Malika, Kottarathil, Tina, Piquet, Michelle, Cao, Yichen, Martinuzzi-Duboc, Laetitia, Buhles, Alexandra, reimann, flavia, Mannino, Salvatore, Laurent, Sansregret, Tordella, Luca, Fedele, Carmine, Maira, Michel, Graus Porta, Diana, Brachmann, Saskia and Sprouffske, Kathleen (2023) Mechanisms of tumor resistance to clinically relevant KRASG12C and SHP2 inhibitor combination in preclinical models of non-small cell lung cancer. Mechanisms of tumor resistance to clinically relevant KRASG12C and SHP2 inhibitor combination in preclinical models of non-small cell lung cancer, 83 (24). pp. 4130-4141.

Presenti, Sara (2023) Synthetic Oligonucleotides synthesis: current process and potential options for the future. Master thesis submitted at Università degli Studi di Perugia, 1 (1). p. 1. ISSN Master thesis submitted at Università degli Studi di Perugia

Prior, Helen, Andrews, Laura, Chien, Hsiaotzu, Clarke, David O, Kaushik, Datta, Dempster, Maggie, Ulrich, Peter, van Meer, Peter and Weir, Lucinda (2023) The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain. Regulatory toxicology and pharmacology : RTP, 138. p. 105339. ISSN 1096-0295

Puckhaber, Daniel, Voges, Anna-Lena, Rane, Supriya, David, Sarah, Gururajan, Bindhu, Finke, Jan Henrik and Kwade, Arno (2023) Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. ISSN 1873-3441

Q

Quancard, Jean, Vulpetti, Anna, Bach, Anders, Cox, Brian, Gueret, Stephanie, Hartung, Ingo, Koolman, Hannes, Laufer, Stefan, Messinger, Josef, Sbardela, Gianluca and Craft, Russel (2023) The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit generation. ChemMedChem : chemistry enabling drug discovery.

R

Raab, Marc S., Cohen, Yael C., Schjesvold, Fredrik, Aardalen, Kimberly, Oka, Adwait, Spencer, Andrew, Wermke, Martin, Souza, Anita D, Kaurman, Jonathan L., Cafro, Anna Maria, Ocio, Enrique M, Doki, Noriko, Henson, Kristin, Trabucco, Gina, Carrion, Ana, Bender, Florent, Juif, Pierre-Eric, Fessehatsion, Adonai, Fan, Liqiong, Stonehouse, Jeffrey, Blankenship, John, Granda, Brian, De Vita, Serena and Lu, Haihui (2023) Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody. Leukemia. ISSN 1476-5551

Rao, Chaitra, Di Lascio, Elena, Demanse, David, Sopala, Monika and De Luca, Valeria (2023) Association of digital measures and self-reported fatigue: a remote observational study in healthy participants and participants with chronic inflammatory rheumatic disease. Frontiers in digital health, 5. p. 1099456. ISSN 2673-253X

Razak, Albiruni R. Abdul, Wang, Hung-Ming, Chang, Jang-Yang, Ahn, Myung-Ju, Munster, Pamela, Blumenschein, George, Solomon, Benjamin, Lim, Darren Wan-Teck, Hong, Ruey-Long, Pfister, David, Saba, Nabil F., Lee, Se-Hoon, Van Herpen, Carla, Quadt, Cornelia, Bootle, Douglas, Blumenstein, Lars, Demanse, David and Delord, Jean-Pierre (2023) A Phase 1b/2 Study of Alpelisib in Combination with Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. Targeted oncology. ISSN 1776-260X

Reidemeister, Sibylle, Nafria Escalera, Begonya, Marín, Daniel, Balayla, Jan, Klingmann, Ingrid and Klingmann, Viviane (2023) Young patients’ involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms. Research Involvement and Engagement., 9 (108). pp. 2-12. ISSN 2056-7529

Reilly, Dorothy, Rocca-Serra, Philippe, Gu, Wei, Ioannidis, Vassilios, Abbassi Daloii, Tooba, Capella-Gutierrez, Salvador, Chandramouliswaran, Ishwar, Splendiani, Andrea, Burdett, Tony, GIessmann, Robert T., Henderson, David, Batista, Dominique, Lister, Allyson, Emam, Ibrahim, Gadiya, Yojana, Giovanni, Lucas, Gray, Alasdair J G, Gribbon, Philip, Juty, Nick, Welter, Danielle, Quast, Karsten, Peeters, Paul, Plasterer, Tom and Sansone, Susanna-Assunta (2023) The FAIR Cookbook - the essential resource for and by FAIR doers. Scientific data, 10 (1). p. 292. ISSN 2052-4463

Reilly, Dorothy, Welter, Danielle, Juty, Nick, Rocca-Serra, Philippe, Xu, Fuji, Henderson, David, Gu, Wei, Strubel, Jolanda, Giessmann, Robert, Emam, Ibrahim, Gadiya, Yojana, Abbassi-Daloii, Tooba, Grey, Alasdair, Courtot, Melanie, Gribbon, Philip, Ioannidis, Vassilios, Lynch, Nick, Boiten, Jan-Willem, Satagopam, Venkata, Goble, Carole, Sansone, Susanna-Assunta and Burdett, Tony (2023) FAIR in action - a flexible framework to guide FAIRification. Scientific data, 10 (1). p. 291. ISSN 2052-4463

Reinhardt, Juergen, Link, Marion, Ibig-Rehm, Yvonne, Schmidt, Isabel, Galuba, Olaf, Schoenbett, Julian, Gasser-Didierlaurent, Christelle, Parker, Christian, Mao, Xiaohong, Bitsch, Francis, Couttet, Philippe, Sigoillot, Frederic, Schirle, Markus, Schmiedeberg, Niko, Muehlemann, Oliver, Gurzeler, Lukas-Adrian, Uldry, Anne-Christine, Ziegelmueller, Jana and Teodorowicz, Wojciech (2023) A novel molecule promotes readthrough at premature stop codons by inducing co-translational degradation of eRF1 involving GCN1, RNF14 and RNF25. Cell reports, 42 (Sep 26). pp. 1-30. ISSN 113056

Reinhardt, Juergen, Link, Marion, Ibig-Rehm, Yvonne, Schmidt, Isabel, Galuba, Olaf, Schoenbett, Julian, Gasser-Didierlaurent, Christelle, Parker, Christian, Mao, Xiaohong, Bitsch, Francis, Couttet, Philippe, Sigoillot, Frederic, Schirle, Markus, Schmiedeberg, Niko, Muehlemann, Oliver, Gurzeler, Lukas-Adrian, Uldry, Anne-Christine and Ziegelmueller, Jana (2023) A novel molecule promotes readthrough at premature stop codons by inducing co-translational degradation of eRF1 involving GCN1, RNF14 and RNF25. Cell reports, 26 (42). pp. 1-30. ISSN 2211-1247

Ren, Xiaojun, Dodd, Stephanie and Basu, Sumit (2023) STREAMLINING FOOD EFFECT ASSESSMENT – ARE REPEAT FOOD EFFECT STUDIES NEEDED? AN IQ ANALYSIS. The AAPS journal, 12248 (822). pp. 1-10. ISSN s12248-023-00822-5

Retson, Laura, Tiwari, Nishant, Vaughn, Jennifer, Bernes, Saunder, Adelson, David, Mansfield, Keith, Libertini, Silvana, Kuzmiski, Brent, Alecu, Iulian, Gabriel, Richard and Mangum, Ross (2023) Epithelioid neoplasm of the spinal cord in a child with spinal muscular atrophy treated with onasemnogene abeparvovec. Molecular therapy : the journal of the American Society of Gene Therapy. ISSN 1525-0024

Richards, Shola, Guo, Fang, Zou, Heng, Nigsch, Florian, Baiges, Anna, Pachori, Alok, Zhang, Yiming, Lens, Sabela, Pitts, Rebecca, Finkel, Nancy, Loureiro, Joe, Mongeon, Dale, Ma, Shenglin, Watkins, Mollie, Polus, Florine, Turon, Fanny, Ferrusquia, Jose, Ble, Michel, Magaz, Marta, Badman, Michael, Sailer, Andreas, Ukomadu, Chinweike, Hernández-Gea, Virginia and Garcia-Pagán, JC (2023) Non-invasive candidate protein signature predicts hepatic venous pressure gradient reduction in cirrhotic patients after sustained virologic response. Liver international : official journal of the International Association for the Study of the Liver, 43 (9). pp. 1984-1994. ISSN 1478-3231

Richards, Shola and Ruffner, Heinz (2023) Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression. International Wound Journal, 21 (4). e14447. ISSN 1742-48011742-481X

Roth, Hans-Joerg, Stein, Richard and Fouche, Marianne (2023) Estimating intrinsic cooperativities and concentrations of ternary complexes in biochemical or cellular environments from binary dissociation constants, apparent cooperativities and total or free ligand concentrations. RSC Chemical Biology themed collection – Molecular Glues.

Roth, Hans-Joerg, Stein, Richard, Fouche, Marianne and Kearns, Jeff (2023) A model-informed method to retrieve intrinsic from apparent cooperativity and project cellular target occupancy for ternary complex-forming compounds. RSC chemical biology, 4 (7). pp. 512-523. ISSN 2633-0679

Roura Padrosa, David, Lehmann, Hansjoerg, Snajdrova, Radka and Paradisi, Francesca (2023) Sustainable synthesis of L-phenylalanine derivatives in continuous flow by immobilized phenyl ammonia lyase. Frontier Catalysis, 3.

S

Sanchez-Felix, Manuel, Bittner, Beate, Lee, Dennis, Horvath, Joshua, Schumacher, Felix and Matoori, Simon (2023) Drug delivery breakthrough technologies – A perspective on clinical and societal impact. Journal of controlled release, 360. pp. 335-343. ISSN 10.1016/j.jconrel.2023.06.034

Santinha, Antonio J., Klingler, Esther, Kuhn, Maria, Farouni, Rick, Lagler, Sandra, Kalamakis, Georgios, Lischetti, Ulrike, Jabaudon, Denis and Platt, Randall (2023) Transcriptional linkage analysis with in vivo AAV-Perturb-seq. Nature, 622 (7982). pp. 367-375. ISSN 1476-4687

Saponara, Enrica, Penno, Carlos, Brun, Virginie, Fischer, Benoit, Brousseau, Margaret, O'Donnell, Peter, Turner, Jonathan, Graff Meyer, Alexandra, Bollepalli, Laura, Roma, Guglielmo, Orsini, Vanessa, Annunziato, Stefano, Obrecht, Michael, Beckmann, Nicolau, Saravanan, Chandrassegar, Tropberger, Philipp, Richards, Shola, Aebi, Alexandra, Ley, Svenja, Ksiazek, Iwona, Genoud, Christel, Nigsch, Florian, Tchorz, Jan, Bouwmeester, Antonius, Ruffner, Heinz, Wang, Zhongyi, Fischer, Audrey, Schadt, Heiko, Matadamas-Guzman, Meztli L, d'Ario, Giovanni, Carbone, Walter, Osmont, Arnaud and Terracciano, Luigi M (2023) Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease. The American Journal of Pathology, 193 (2). pp. 161-181. ISSN https://www.sciencedirect.com/science/article/pii/S0002944022003583?via%3Dihub

Schiller, Hilmar (2023) IQ Therapeutic Protein Drug-Drug Interaction White Paper. Clinical Pharmacology & Therapeutics. ISSN 0009-92361532-6535

Schiller, Hilmar (2023) Industry Perspective on Therapeutic Peptide Drug-Drug Interaction Assessments During Drug Development: A European Federation of Pharmaceutical Industries and Associations White Paper. Clinical pharmacology and therapeutics. ISSN 1532-6535

Schmidt-Morgenroth, Ines, Avrameas, Alexandre, Gasparini, Fabrizio and Michaud, Philippe (2023) Central and Peripheral Inflammation in Mild Cognitive Impairment in the Context of Alzheimer's Disease. International journal of molecular sciences, 24 (13). ISSN 1422-0067

Schneider, Nadine, Lanini, Jessica, Rodriguez Perez, Raquel, Grisoni, Francesca, Nittinger, Eva, Riniker, Sereina, Andrea, Volkamer and Emma, Evertsson (2023) Machine Learning for Small Molecule Drug Discovery in Academia and Industry. Artificial Intelligence in the Life Sciences, 3. ISSN 26673185

Schroeder, Martin, Thoma, Claudio, Liang, Xiaoyou, Hofmann, Andreas, Meili, Fabian, Thomas, Jason, Sigoillot, Frederic, Gleim, Scott, Vulpetti, Anna, Zoller, Thomas, Ferrand, Sandrine, Chung, BoYee, Andraos-Rey, Rita and Niederst, Matt (2023) Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings. BioRxiv.

Schubart Wellensiek, Anna, Flohr, Stefanie, Junt, Tobias and Eder, Joerg (2023) Low-molecular weight inhibitors of the alternative complement pathway. Immunological Reviews, 313 (1). pp. 339-357. ISSN 0105-28961600-065X

Schuetz, Stefan, Bergsdorf, Christian, Haenni-Holzinger, Sandra, Lingel, Andreas, Renatus, Martin, Gossert, Alvar D. and Jahnke, Wolfgang (2023) Intrinsically disordered regions in the transcription factor MYC:MAX modulate DNA binding via intramolecular interactions. bioRxiv.

Seelinger, Felix (2023) Complex binding and elution behavior of therapeutic proteins under column overloading conditions. heiDOK – The Heidelberg Document Repository.

Sellner, Holger, Chapeau, Emilie, Furet, Pascal, Voegtle, Markus, Le Douget, Mickael, Bordas, Vincent, Le Goff, Anne-Laure, Rouzet, Christine, Wietlisbach, Thomas, Brocklehurst, Cara, Chene, Patrick, Wartmann, Markus, Scheufler, Clemens, Williams, Gareth, Traebert, Martin, Dumotier, Berengere, Schmelzle, Tobias, Soldermann, Nicolas and Zimmermann, Thomas (2023) Optimization of a Class of Dihydrobenzofurane Analogs Toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. ChemMedChem : chemistry enabling drug discovery.

Serrano Fernandez, Pablo, Kaiser, Sergio, Zhang, Luqing, Dovlatyan, Mary, Sanz, Vinicius, Li, Jingyao, Kostikova, Anna, Rotte, Michael and Messa, Mirko (2023) Parkinson’s disease causality and heterogeneity: a proteogenomic view. NPJ parkinson's disease, 9 (1). p. 24. ISSN 23738057

Shaw, Duncan, Smith, Nichola, Cotesta, Simona, Williams, Gareth, Sohal, Bindi, Rynn, Caroline, Troxler, Thomas J., D'Souza, Anne-Marie, Lattmann, Rene, Beerli, Rene, Pulz, Robert, Guth-Gundel, Sabine and Rowlands, David (2023) Design and synthesis of inhibitors of the E3 ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) as a treatment for lung remodeling in Pulmonary Arterial Hypertension (PAH). Journal of medicinal chemistry. ISSN 1520-4804; 0022-2623

Shi, Tiffany, Burg, Ashley R., Caldwell, J. Tim, Roskin, Krishna, Castro-Rojas, Cyd M., Chukwuma, P. Chukwunalu, Gray, George, Alonso, Jesus, Cuda, Carla, Allman, David A., Rush, James, Regnier, Catherine, Wieczorek, Grazyna, Alloway, Rita R., Shields, Adele R., Baker, Brian M., Woodle, E. Steve and Hildeman, David A. (2023) SINGLE CELL TRANSCRIPTOMIC ANALYSIS OF RENAL ALLOGRAFT REJECTION REVEALS NOVEL INSIGHTS INTO INTRAGRAFT TCR CLONALITY. The Journal of clinical investigation : JCI. ISSN 1558-8238; 0021-9738

Shisha, Tamas, Posch, Maximilian G, Jeanette, Lehmann, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard and Gergely, Peter (2023) First-in-human study of safety, pharmacokinetics, and pharmacodynamics of MHV370, a dual inhibitor of Toll-like receptors 7 and 8, in healthy adults. European Journal of Drug Metabolism and Pharmacokinetics, 1 (1). pp. 1-14. ISSN 21070180

Siirola, Elina Maria, Snajdrova, Radka, Lutz, Stefan, Braun, Markus, Gruber, Christian, Krassnigg, Andreas, Kummer, Arkadij and Oberdorfer, Gustav (2023) Accelerating Biocatalysis Discovery with Machine Learning: A New Era in Enzyme Engineering new title based on editors feedback: Accelerating Biocatalysis Discovery with Machine Learning: A Paradigm Shift in Enzyme Engineering, Discovery, and Design. ACS Catalysis, 13 (21). pp. 14454-14469.

Simeoni, Philippe, Deissler, Michael, Bienert, Roland, Gritsch, Manuela, Nerkamp, Joerg, Kirsch, Stephan, Pohl, Thomas, Anderka, Oliver and Christoph, Roesli (2023) Using enhanced development tools offered by analytical Quality by Design to support switching of an analytical quality control method. Using enhanced development tools offered by analytical Quality by Design to support switching of a quality control method. pp. 1-12. ISSN doi.org/10.1002/bit.28517

Simwela, Nelson V, Guiguemde, Armand, Straimer, Judith, Regnault, Clement, Yokokawa, Fumiaki, Taft, Benjamin, Diagana, Thierry, Barrett, Michael P, Waters, Andrew P, Stokes, Barbara H and Tavernelli, Luis E (2023) A conserved metabolic signature associated with response to fast-acting anti-malarial agents. Microbiology spectrum, 11. ISSN 2165-0497

Snajdrova, Radka, Buller, Rebecca, Lutz, Stefan, Moore, Jeffrey, Kazlauskas, Romas and Bornscheuer, Uwe (2023) Surfing the biocatalysis wave to new applications Changed to: From nature to industry: Harnessing enzymes for biocatalysis, as per request of Editor. Science, 382 (6673).

Snajdrova, Radka, Siirola, Elina Maria, Eggimann, Fabian, Vargas, Alexandra, Schroer, Kirsten, Peschke, Theo, Schlama, Thierry and Moore, Charles (2023) Evolution of Biocatalysis at Novartis over Last 40 Years. CHIMIA, 77 (6). pp. 376-383. ISSN doi:10.2533/chimia.2023.376

Stange, Carolin, Hafiz, Supriyadi, Erwin, Nelli, Hafner, Mathias and Frech, Christian (2023) Two peak elution behavior of a monoclonal antibody in cation exchange chromatography as a screening tool for excipients. Journal of Chromatography B, 1214 (123563). ISSN 15700232

Stringer, Rowan, Chen, Jin, Shah, Bharti, Gu, Jessie, Zhang, Yiming, Prince, William, Klickstein, Lloyd and Woessner, Ralph (2023) A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants. Clinical pharmacology in drug development, 12 (2). pp. 117-230. ISSN DOI: 10.1002/cpdd.1208

Sturm, Noe, Heyndrickx, Wouter, Arany, Adam, Simm, Jaak, Pentina, Anastasia, Humbeck, Lina, Mervin, Lewis, Zalewski, Adam, Oldenhof, Martijn, Schmidtke, Peter, Friedrich, Lukas, Loeb, Regis, Afanasyeva, Arina, Moreau, Yves and Ceulemans, Hugo (2023) Conformal efficiency as a metric for comparative model assessment befitting federated learning. Artificial Intelligence in the Life Sciences, 3. ISSN 26673185

Sutherland, Jeffrey, Yonchev, Dimitar, Fekete, Alexander and Urban, Laszlo (2023) A novel preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs. Nature Communications, online (online). pp. 1-17.

Sverdlov, Alex, Carter, Kerstine, Hilgers, Ralf-Dieter, Everett, Colin C., Berger, Vance W., Luo, Yuqun Abigail, Chipman, Jonathan J., Ryeznik, Yevgen, Ross, Jennifer, Knight, Ruth and Yamada, Kazumi (2023) Which Randomization Methods Are Used Most Frequently in Clinical Trials? Results of a Survey by the Randomization Working Group. Statistics in biopharmaceutical research.

Sverdlov, Alex and Ryeznik, Yevgen (2023) Balancing the Objectives of Statistical Efficiency and Allocation Randomness in Randomized Controlled Trials. Statistics in biopharmaceutical research. pp. 1-32. ISSN 1946-6315

Szapacs, Matt, Jian, Wenying, Spellman, Daniel, Cunliffe, Jennifer, Verburg, Elizabeth, Kaur, Surinder, Kellie, John, Li, Wenkui, Mehl, John, Qian, Mark, Qiu, Xiazi, Sirtori, Federico Riccardi, Rosenbaum, Anton I., Sikorski, Tim, Surapaneni, Sekhar, Wang, Jian, Wilson, Amanda, Zhang, Jinhui, Post, Noah, Xue, Yongjun, Goykhman, Dina, Huang, Yue, Fang, Kasie, Yuan, Long, Chen, Linzhi, Huang, Ming, Casavant, Ellen, Fu, Yunlin, Ji, Allena, Johnson, Jay, Lassman, Michael, Li, Jing, Saad, Ola, Sarvaiya, Hetal, Wang,, Yuting, Tao, Lin and Zheng, Naiyu (2023) 2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine). Bioanalysis, 15 (16). pp. 955-1016. ISSN 1757-6199

T

Tchorz, Jan and Schoenberger, Katharina (2023) Hepatic stellate cells mediate homeostatic hepatocyte proliferation. Science Signaling.

Teng, Chi-Hse (2023) Report on Pharmaceutical Industry Survey of Nonclinical Statistics resources. ASA Biopharm report, 30 (3).

Terranova, Nadia, Renard, Didier, Shahin, Mohamed, Menon, Sujetha, Cao, Youfang, Hop, Cornelis, Hayes, Sean, Stodtmann, Sven, Tensfeldt, Thomas, Vaddady, Pavan, Ellinwood, Nicholas and Lu, James (2023) Artificial Intelligence for Quantitative Modeling in Drug Discovery and Development: An Innovation and Quality Consortium Perspective on Use Cases and Best Practices. Clinical Pharmacology & Therapeutics, 115 (4). pp. 658-672. ISSN 0009-92361532-6535

Thibodeaux, Stefan, Duong, Lisa, Altinoglu, Erhan, Dimke, Thomas, Shaw, Duncan, Rowlands, David and Growcott, Ellena (2023) Aerosol technology to mimic dry powder inhalation in vitro using pulmonary cell models. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. ISSN 1873-3441

Thoma, Gebhard, Decoret, Odile, Vangrevelinghe, Eric, Trunzer, Markus, Decker, Andrea, Bruno, Sandro, Hauchard, Alice and Hacini-Rachinel, Feriel (2023) Design of a Super-Soft Topical JAK Inhibitor, which Is Efficacious in Human Skin but Rapidly Deactivated in Blood. Journal of medicinal chemistry, 66. pp. 15042-15053.

Thoma, Gebhard, Duthaler, Rudolf, Waelchli, Rudolf, Hauchard, Alice, Bruno, Sandro, Strittmatter-Keller, Ulrike, Viebrock, Sabine, Aichholz, Reiner, Beltz, Karen, Grove, Kerri, Hoque, Shaila, Rudewicz, Patrick and Zerwes, Hans Guenter (2023) Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. Journal of medicinal chemistry. ISSN 1520-4804

Thoma, Gebhard, Markert, Christian, Spanka, Carsten, Srinivas, Honnappa, Penno, Carlos, Kiffe, Michael, Gajewska, Monika, Bednarczyk, Dallas, Wieczorek, Grazyna, Evans, Amanda, Roehn, Till, Lueoend, Rainer, Miltz, Wofgang, Bollbuck, Birgit and Wolf, Romain (2023) Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. Journal of medicinal chemistry, 66 (23). pp. 16410-16425. ISSN 1520-4804

Thoma, Gebhard, Vangrevelinghe, Eric, Luneau, Alexandre, Piechon, Philippe, Beerli, Christian and Zerwes, Hans Guenter (2023) Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation. ACS medicinal chemistry letters, 14. ISSN 1948-5875

Tin, Adrienne, Gudmundsdottir, Valborg, Emilsson, Valur, Launer, Lenore J, Jennings, Lori and Gudnason, Vilmundur (2023) Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Communications biology, 6 (1). p. 1117. ISSN 2399-3642

Tkacik, Emre, Li, Kunhua, Gonzalez-Del Pino, Gonzalo, Ha, Byung Hak, Vinals, Javier, Park, Eunyoung, Beyett, Tyler and Eck, Michael J. (2023) Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib. The Journal of biological chemistry, 299 (5). p. 104634. ISSN 1083-351X

Tomic, Ivana, Hingle, Martin and Forbes, Ben (2023) The importance of dissolution for orally inhaled drug products: pharmaceutical, regulatory, and clinical considerations. Expert opinion on drug delivery. pp. 1-4. ISSN 1744-7593

Toriki, Ethan, Papatzimas, James, Nishikawa, Kaila, Dovala, Dustin, McGregor, Lynn, Hesse, Matthew, McKenna, Jeffrey, Tallarico, John, Schirle, Markus and Nomura, Daniel (2023) Rational Chemical Design of Molecular Glue Degraders. ACS central science, 9 (5). pp. 915-926. ISSN 2374-7943

Tosco, Paolo (2023) MCS: What's new. RDKit blog.

Toth, Linda, Gades, Naomi, DeMarco, George, Gaskill, Brianna and Tolley, Elizabeth (2023) Opinion: Common Errors, Omissions, and Presentation Problems in the Conduct and Reporting of Animal-based Research. Journal of the American Association for Laboratory Animal Science : JAALAS. ISSN 2769-6677

Treton, Gwenola, Sayer, Claudia, Schürz, Melanie, Jaritsch, Maria, Mueller, Anna, Matea, Cristian-Tudor, Stajnolovic, Vesna, Melo-Benirschke, Heloisa, Be, Celine, Krembel, Caroline, Rodde, Stephane, Haffke, Matthias, Hintermann, Samuel, Marzinzik, Andreas, Ripoche, Sebastien, Bloechl, Constanin, Hollerweger, Julia, Auer, Daniela, Cabrele, Chiara, Huber, Christian, Hintersteiner, Martin, Wagner, Beatrix, Lingel, Andreas and Meisner-Kober, Nicole (2023) Quantitative and functional characterisation of extracellular vesicle loading with small molecules by passive adsorption versus cholesterol mediated membrane anchoring. Journal of controlled release, 361. pp. 694-716. ISSN 1873-4995; 0168-3659

Tu, Hang-Fei, Jeandin, Aliénor, Bon, Corentin, Brocklehurst, Cara, Lima, Fabio and Suero, Marcos G. (2023) Late-Stage Aryl C-H Bond Cyclopropenylation with Cyclopropenium Cations. Angewandte Chemie (International ed. in English). e202308379. ISSN 1521-3773

Twarog, Michael, Schustak, Joshua, Xu, YongYao, Coble, Matthew, Dolan, Katie, Esterberg, Robert, Huang, Qian, Saint-Geniez, Magali and Bao, Yi (2023) TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function. Scientific reports, 13 (1). p. 14451. ISSN 2045-2322

U

Ullah, Md Mahbub, Collett, Jason A., Bacallao, Robert L. and Basile, David P. (2023) Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery. American Journal of Physiology-Renal Physiology. ISSN 1931-857X

V

Valencia-Sama, Ivette, Kee, Lynn, Christopher, Gabriella, Ohh, Michael, Hayes, Madeline, Irwin, Meredith S., Kee, Lynn, Mehdi, Layeghifard and Adam, Shlien (2023) SHP2 INHIBITOR TNO155 SYNERGIZES WITH ALK INHIBITORS IN ALK-DRIVEN NEUROBLASTOMA MODELS. Clinical cancer research, 3 (12). pp. 2608-2622. ISSN 2767-9764

Ventre, Katherine, Roehle, Kevin, Bello, Elisa, Bhuiyan, Aladdin, Biary, Tamara, Crowley, Stephanie, Bruck, Patrick, Heckler, Max, Lenehan, Patrick, Ali, Lestat, Stump, Courtney, Lippert, Victoria, Clancy-Thompson, Eleanor, Conce Alberto, Winiffer D., Hoffman, Megan, Qiang, Li, Pelletier, Marc, Akin, James, Dougan, Michael and Dougan, Stephanie (2023) cIAP1/2 antagonism induces antigen-specific T cell dependent immunity. The journal of immunology, 210. pp. 991-1003. ISSN 1550-6606

Vulpetti, Anna, Holzer, Philipp, Schmiedeberg, Niko, Imbach-Weese, Patricia, Pissot Soldermann, Carole, Hollingworth, Greg, Radimerski, Thomas, Thoma, Claudio, Stachyra, Therese-Marie, Wojtynek, Matthias, Chau, Suzanne, Schuffenhauer, Ansgar, Fernandez, Cesar, Schroeder, Martin and Renatus, Martin (2023) Discovery of new binders for DCAF1, an emerging ligase target in the Targeted Protein Degradation field. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

W

Walles, Markus (2023) Meeting report of the third European Biotransformation Workshop. Xenobiotica. pp. 1-5. ISSN doi: 10.1080/00498254.2023.2173105

Wallimann, Rahel, Schindler, Patrick, Hensinger, Heloise, Kneuer, Rainer, Tschan, Viviane, Busslinger, Sarah, Müller, Cristina and Schibli, Roger (2023) High-sensitivity ICP-MS is a valid method for the preclinical characterization of metal-conjugates to be developed as future radiopharmaceuticals. Molecular pharmaceutics, 20 (4). pp. 2150-2158. ISSN 1543-8384

Wartchow, Charles (2023) Biophysical and structural studies of the ligand-induced interaction of multiple SALL4 zinc finger domains with cereblon. N/A.

Wartchow, Charles (2023) Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Scientific reports, 13 (1). p. 22088. ISSN 2045-2322

Wartchow, Charles, Chie Leon, Barbara, Ornelas, Elizabeth, Dovala, Dustin, Luu, Catherine, Pardee, Gwynn, Widger, Stephania, Solomon, Jonathan, Moser, Heinz and Clifton, Matt (2023) Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Scientific reports, 13 (1). p. 22088. ISSN 2045-2322

Weber, Hans-Jochen, Corson, Stephen, Li, Jiang, Mercier, Francois, Roychoudhury, Satrajit, Sailer, Martin Oliver, Sun, Stephen, Todd, Alexander and Yung, Godwin (2023) Duration of and time to response in oncology clinical trials from the perspective of the estimand framework. Pharmaceutical Statistics. pp. 1-16. ISSN 1539-16041539-1612

Wei, Cindy, Popp, Nicholas A, Peleg, Omri, Powell, Rachel L, Borenstein, Elhanan, Maly, Dustin J and Fowler, Douglas M (2023) A chemically controlled Cas9 switch enables temporal modulation of diverse effectors. Nature chemical biology. ISSN 1552-4469

Welte, Thomas, Goulois, Alison, Neagu, Anca, Azzi, Chiara, Lübke, Marlena, Stadler, Michael, Hess, Daniel, Schmidt, Isabel, Estoppey, David, Nigsch, Florian, Reece-Hoyes, John, Hoepfner, Dominic and Grosshans, Helge (2023) Convergence of distinct RNA-silencing pathways on GW182/Tnrc6. Molecular Cell, 83 (14). pp. 2478-2492. ISSN https://doi.org/10.1016/j.molcel.2023.06.001

Werthmueller, Dominic, Schlauersbach, Jonas, Harlacher, Cornelius, Galli, Bruno, Hanio, Simon, Lenz, Bettina, Endres, Sebastian, Pöppler, Ann-Christin, Scherf-Clavel, Oliver and Meinel, Lorenz (2023) Harnessing Bile for Drug Absorption through Rational Excipient Selection. Molecular pharmaceutics. ISSN 1543-8392

Whicher, Jonathan (2023) Novartis overcomes space limitations to bring high-quality data analysis on-site. The structure of life.

Widmer, Lukas Andreas, Bean, Andrew, Ohlssen, David and Weber, Sebastian (2023) Principled Drug-Drug Interaction Terms for Bayesian Logistic Regression Models of Drug Safety in Oncology Phase I Combination Trials. arXiv.

Widmer, Toni, Sanchez-Felix, Manuel, Donglei, Leng, Bulduk, Bulut and Löbmann, Korbinian (2023) Protein based amorphous solid dispersion: A case study investigating different whey proteins at high drug loading. Pharmaceutical research.

Winter, Serge (2023) Supported liquid extraction combined with liquid chromatography tandem mass spectrometry for the quantitative analysis of a TLR7 agonist imiquimod LFX453 in plasma at low picogram per milliliter: method validation and its application to pharmacokinetic study in minipig. Biomedical chromatography BMC.. ISSN 0269-3879

X

Xu, Dongchu, Cunningham, Jonathan, Marti-Castellote, Pablo-Miki, Zhang, Luqing, Patel-Murray, Natasha, Prescott, Margaret, Chutkow, William, Mendelson, Michael, Solomon, Scott and Claggett, Brian (2023) Machine Learning for Proteomic Risk Scores in Heart Failure. Journal of cardiac failure. ISSN 1532-8414; 1071-9164

Xu, Siyan, Zhang, Na, Rinne, Mikael L., Sun, Haiying and Stein, Andrew (2023) Sabatolimab (MBG453) model-informed drug development for dose selection in patients with myelodysplastic syndrome/acute myeloid leukemia and solid tumors. CPT: pharmacometrics & systems pharmacology. ISSN 2163-8306

Y

Yang, Linhong and Skolnik, Suzanne (2023) Avoid missing pKas: high throughput workflow using solution pH-metric in tandem with UV-metric measurements. Journal of pharmaceutical and biomedical analysis, 234 (115530). ISSN 1873-264X; 0731-7085

Yates, Denise, Revaiah, PC, Serruys, PW, Onuma, Y and Zamorano, JL (2023) Glagov revisited: coronary artery disease phenotype on non-invasive imaging provides rationale for implementing preventive pharmacotherapy-a case report. European heart journal. Case reports, 7 (9). ytad416. ISSN 2514-2119

Young, Graeme C, Spracklin, Douglas K, James, Alexander David, Hvenegaard, Mette G, Pedersen, Mette L, Wagner, David S, Georgi, Katrin, Schieferstein, Hanno, Bjornsdottir, Inga, Romeo, Andrea A, Cassidy, Kenneth C, Da-Violante, Georges, Blech, Stefan, Hoffman, Matthew, Schulz, Simone I, Cuyckens, Filip, Nguyen, Mai Anh and Scarfe, Graeme (2023) Non-labelled, Stable Labelled or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: a Discussion Piece. Clinical pharmacology and therapeutics. ISSN 1532-6535

Z

Zhai, Jin, Traebert, Martin, Zimmermann, Kurt, Delaunois, Annie, Royer, Leandro, Salvagiotto, Giorgia, Carlson, Coby and Lagrutta, Armando (2023) Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability. Journal of pharmacological and toxicological methods. p. 107297. ISSN 10.1016

Zhou, Yu and Wang, Yueju (2023) Direct Deamidation Analysis of Intact Adeno-Associated Virus Serotype 9 (AAV9) Capsid Proteins using Reversed-Phase Liquid Chromatography (RPLC)- Tandem Mass Spectrometry (MS) or RPLC-Fluorescence Detector (FLD). Analytical biochemistry, 668 (115099). pp. 1-9. ISSN Print ISSN: 0003-2697; Online ISSN: 1096-0309

Ziegler, Jonathan D. (2023) The Digital Patient - How synthetic data can advance medical research. Medium.

Zvornicanin, Sarah, Shaqra, Ala, Huang, Qiu Yu, Ornelas, Elizabeth, Moghe, Mallika, Knapp, Mark, Moquin, Stephanie, Dovala, Dustin, Schiffer, Celia and Yilmaz, Nese (2023) Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses, 15 (3). ISSN 1999-4915

This list was generated on Sun Oct 6 01:51:46 2024 UTC.

Search