Gallou, Fabrice (2023) Ligand-Free Regioselective Aromatic Hydrogenation of Phosphine Oxide Scaffolds: An Easy Access to New Phosphine Ligands. Angewandte Chemie. International edition, 2023. ISSN 1521-3773; 0570-0833; 1433-7851

Abstract

Herein, we described the first semi- and regioselective hydrogenation of P(V)-substituted naphthalenes. This ligand-free iridium-catalyzed reaction delivers phosphine oxides or phosphonates in almost quantitative yields and with total regioselectivity. This report also exposed a novel pathway toward the preparation of H8-BINAP ligands derivatives. The importance of HFIP solvent is also evidenced by 1H-NMR experiments. Catalyst analysis also demonstrated the involvement of ultrasmall iridium(0) nanoparticles and the potential recycling of the catalyst was also showcased

Item Type:	Article
Date Deposited:	01 Sep 2023 00:45
Last Modified:	01 Sep 2023 00:45
URI:	https://oak.novartis.com/id/eprint/48840