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Recent progress in water-based Sonogashira cross-couplings in water

Gallou, Fabrice (2023) Recent progress in water-based Sonogashira cross-couplings in water. Chem Catalysis, 3 (1). 100485,. ISSN 2667-1093


During the past five decades, a number of transition metal catalyzed cross-coupling reactions became indispensable to the toolbox of organic chemists, finding a wide range of applications in all industries, and in particular in the agrochemical and pharmaceutical industry.[1] Specifically, palladium-catalyzed cross-coupling reactions have matured to become highly effective methods for efficient CC bond formation. Since the first procedures in the 1970’s,[2] significant progress was achieved thanks to ligand-design that have been resulting into a wide range of applications. The enormous impact of these broadly applicable CC bond forming reactions was recognized in 2010 with the Nobel Prize attributed to R. F. Heck, E.i. Negishi, and A. Suzuki in 2010.[1b, 3] Among the developed cross-coupling reactions, the Sonogashira reaction has shown to be a powerful procedure to construct valuable internal alkynes predominantly using palladium catalysts and copper as co-catalyst.[4] More recently several copper-free procedures have been developed.[5] Further illustrating the impact of the transformation in biological active compounds or intermediates, the Sonogashira reaction is also often found in their synthesis

Item Type: Article
Date Deposited: 14 Feb 2023 00:45
Last Modified: 14 Feb 2023 00:45