Grandeury, Arnaud, De Caro, Liberato, Del Giudice, Alessandra, Giannini, Cinzia, Gozzo, Fabia, Morin, Mickael and Reinle-Schmitt, Mathilde (2023) Small Angle X-ray Scattering data analysis and theoretical modelling for the size and shape characterization of drug delivery systems based on Vitamin E TPGS micelles. Journal of pharmaceutical sciences, 112 (1). pp. 243-249. ISSN 10.1016/j.xphs.2022.09.029

Abstract

We developed a simple two-dimensional/two-components theoretical model that describes the structure and functionality of a VitE-TPGS system of micelles assuming a hydrophobic inner core and an outer hydrated hydrophilic shell. We then conceptually applied the developed methodology to a simple system of VitE-TPGS micelles unloaded and loaded with an active pharmaceutical ingredient to verify if the model could reliably monitor the size change of the micelle. The fit of laboratory Small Angle X-Ray Scattering data against such model allows us to extract absolute values of the micelles’ size under a spherical shape hypothesis as well as the distribution within the system between components and level of hydration. The intensity scale of the SAXS experimental data need to be normalized to a reference standard (pure water) to get absolute scattered intensities. The mathematical model which has been developed under a general hypothesis of ellipsoidal micelles, is applied to our experimental data under the simplified spherical assumption, which suitably fit our experimental data.

Item Type:	Article
Keywords:	Drug Delivery Systems, Vitamin E-TPGS, Active Pharmaceutical Ingredients, Small Angle Scattering, micelles
Date Deposited:	27 Mar 2024 00:45
Last Modified:	27 Mar 2024 00:46
URI:	https://oak.novartis.com/id/eprint/47165