Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Drug delivery breakthrough technologies – A perspective on clinical and societal impact

Sanchez-Felix, Manuel, Bittner, Beate, Lee, Dennis, Horvath, Joshua, Schumacher, Felix and Matoori, Simon (2023) Drug delivery breakthrough technologies – A perspective on clinical and societal impact. Journal of controlled release, 360. pp. 335-343. ISSN 10.1016/j.jconrel.2023.06.034


The way a drug molecule is administered has always had a profound impact on people requiring medical interventions - from vaccine development to cancer
therapeutics. In the Controlled Release Society Fall Symposium 2022, a trans-institutional group of scientists from industry, academia, and non-governmental or�ganizations discussed what a breakthrough in the field of drug delivery constitutes. On the basis of these discussions, we classified drug delivery breakthrough
technologies into three categories. In category 1, drug delivery systems enable treatment for new molecular entities per se, for instance by overcoming biological
barriers. In category 2, drug delivery systems optimize efficacy and/or safety of an existing drug, for instance by directing distribution to their target tissue, by
replacing toxic excipients, or by changing the dosing reqimen. In category 3, drug delivery systems improve global access by fostering use in low-resource settings, for
instance by facilitating drug administration outside of a controlled health care institutional setting. We recognize that certain breakthroughs can be classified in more
than one category. It was concluded that in order to create a true breakthrough technology, multidisciplinary collaboration is mandated to move from pure technical
inventions to true innovations addressing key current and emerging unmet health care needs.

Item Type: Article
Date Deposited: 06 Oct 2023 09:11
Last Modified: 06 Oct 2023 09:30


Email Alerts

Register with OAK to receive email alerts for saved searches.