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Bartko, Theresa, Lutgen, Stephen, Ross, Rebecca, Walisser, Jacqueline, Garske, Eric, Kopelke, Kerry, Ashcroft-Hawley, Kelly, Tang, Hai-Ming, Kremer, John, Friedrichs, Gregory and Nichols, Jill (2024) Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone. Journal of pharmacological and toxicological methods. p. 107527. ISSN 1873-488X

Bechtold-Peters, Karoline and Roesti, David (2024) Risk-based approach to setting sterile filtration microbial bioburden limits - Focus on biotech-derived products. European journal of pharmaceutics and biopharmaceutics, 198 (114151). ISSN 1873-3441; 0939-6411

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Bihlet, Asger Reinstrup, Balchen, Torben, Goteti, Kosalaram, Sonne, Jesper, Ladel, Christoph, Karsdal, Morten Asser, Ona, Victor, Moreau, Flavie, Waterhouse, Roseann, Bay-Jensen, Anne-Christine and Guering, Hans (2024) Safety, Tolerability, and Pharmacodynamics of the ADAMTS-5 Nanobody M6495: Two Phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled Studies in Healthy Subjects and Patients With Osteoarthritis. ACR open rheumatology, 6 (4). pp. 205-213. ISSN 2578-5745

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Brennan, Richard, Jenkinson, Stephen, Brown, Andrew, Delaunois, Annie, Dumotier, Berengere, Pannirselvam, Malar, Rao, Mohan, Ribeiro, Lyn, Schmidt, Friedemann, Sibony, Alicia, Timsit, Yoav, Sales, Vicencia, Armstrong, Duncan, Lagrutta, Armando, Mittelstadt, Scott, Naven, Russ, Peri, Ravikumar, Roberts, Sonia, Vergis, James and Valentin, Jean-Pierre (2024) Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines. Nature reviews. Drug discovery. ISSN 1474-1784

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Brown, Alan, Friedrichs, Gregory, Traebert, Martin, Weber, Valerie, Yao, Nancy, Tang, Hai-Ming and Yan, Gan-Xin (2024) Electrophysiological changes in the rabbit ventricular wedge assay and in human-induced pluripotent stem-cell derived (IPSC) cardiomyocytes provided correlates to severe arrhythmia observed in a dog toxicology study, whereas standard in vitro ion channel assays were not predictive of adverse cardiovascular change. International Journal of Toxicology. pp. 1-12. ISSN DOI: 10.1177/10915818241230900

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CHao, Hu, Jet, Tsien, Si-Jie, Chen, May, Kong, Rohan. R, Merchant, Kanda, Yuzuru and Tian, Qin (2024) A General Three-Component Alkyl Petasis Boron-Mannich Reaction. Journal of the American Chemical Society, 146 (31). pp. 21769-21777. ISSN 1520-5126

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Cas, Wognum, Jeremy R., Ash, Aldeghi, Matteo, Rodriguez Perez, Raquel, Cheng, Fang, Cheng, Alan C., Price, Daniel J., Clevert, Djork-Arné, Engkvist, Ola and Walters, W. Patrick (2024) A call for an industry-led initiative to critically assess machine learning for real-world drug discovery. Nature Machine Intelligence.

Chapeau, Emilie, Schmelzle, Tobias and Soldermann, Nicolas (2024) Direct and selective pharmacological disruption of the YAP-TEAD interface inhibits cancers with genetic alterations in the Hippo and RAS-MAPK pathways. Nature Cancer.

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Chen-Yan, Cai, Si-Jie, Chen, Rohan R., Merchant, Tian, Qin and Kanda, Yuzuru (2024) C3 Selective Hydroxylation of Pyridines via Photochemical Valence Isomerization of Pyridine N-OxidesArticle link copied! Journal of American Chemical Society, 146 (35). pp. 24257-24264.

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Claas, Allison, Lee, Meelim, Huang, Pai-Hsi, Knutson, CHARLIE, Bullara, Dom, Schoeberl, Birgit and Gaudet, Suzanne (2024) Viral Kinetics Model of SARS-CoV-2 Infection Informs Drug Discovery, Clinical Dose, and Regimen Selection. Clinical pharmacology and therapeutics. ISSN 1532-6535

Combes, Francois Pierre, Li, Ying Fei, Sy, Sherwin, Lorenzo, Sebastien, Dasgupta, Kohinoor, Kapoor, Shruti, Hoch, Matthias and Ho, Yu-Yun (2024) Dose Justification for Asciminib in Patients With Philadelphia Chromosome-Positive Chronic Myeloid Leukemia With and Without the T315I Mutation. Clinical Pharmacokinetics, 63 (9). pp. 1301-1312. ISSN 39243304

Constantine, LA, Davidson, T, Häner, A, Janer Gual, Gemma, Maynard, SK, Lee, M, Perkins, AN, Ryan, JJ, Tell, J, Van Ginneken, I, Burden, N and Dolan, D (2024) EVALUATION OF THE EMA TRIGGER FOR FISH BCF TESTING AND SECONDARY POISONING ASSESSMENT: EVALUATION OF LOG D AND FISH BCF DATA FOR SEVERAL PHARMACEUTICALS. Regulatory toxicology and pharmacology, 151 (105651). pp. 1-11. ISSN 1096-0295; 0273-2300

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Daniel, Puckhaber, Jan Henrik, Finke, David, Sarah, Gururajan, Bindhu, Rane, Supriya and Arno, Kwade (2024) Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose. International journal of pharmaceutics. p. 123792. ISSN 1873-3476

Danilack, Aaron, Dickson, Callum, Soylu, Cihan, Fortunato, Mike, Rodde, Stephane, Hornak, Viktor and Duca, Jose (2024) Reactivities of acrylamide warheads toward cysteine targets: a QM/ML approach to covalent inhibitor design. Journal of chemical information and modeling, 38 (21).

Das, Moushumi, Semple, Jennifer I, Haemmerli, Anja, Volodkina, Valeriia, Scotton, Janik, Gitchev, Todor, Annan, Ahrmad, Campos, Julie, Statzer, Cyril, Dakhovnik, Alexander, Ewald, Collin Y, Mozziconacci, Julien and Meister, Peter (2024) Condensin I folds the Caenorhabditis elegans genome. Nature genetics, 56 (8). pp. 1737-1749. ISSN 1546-1718

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Degtyarev, Evgeny, Bolanos, Natacha, Brody, Joshua, Buchbinder, Aby, Buyse, Marc, Fuchs, Miriam, Halabi, Susan, Hemmings, Robert, Masood, Aisha, Newsome, Simon, Saxton, Claire, Warwick, Lorna, Yateman, Nigel and Zuber, Emmanuel (2024) End points in clinical trials in diffuse large B-cell lymphoma: time for more dialogue? Future oncology (London, England). pp. 1-15. ISSN 1744-8301

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Dhareshwar, Sundeep, Matharu, Amol and Cao, Yu(Jade) (2024) Identifying chemical stabilizers - presenting a case study using a rapid 3-day accelerated excipient screening methodology. AAPS PharmSciTech, 12 (25). ISSN 1530-9932

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Dolan, Katie, Liao, Sha-Mei, Crowley, Maura, Xiang, Chuanxi, Adams, Christopher, Brown, Ann, Vo, Nhi, Chen, Amy, Delgado, Omar, Buchanan, Natasha, Guo, Chenying and Prasanna, Ganesh (2024) Complement factor B inhibition or deletion is not sufficient to prevent neurodegeneration in a murine model of glaucoma. Journal of ocular pharmacology and therapeutics. ISSN 38976487

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Xu, Lanting, Zhu, Jiazhou, Shen, Xiaodong, Chai, Jiashuang, Shi, Lei-1, Wu, Bin, Li, Wei and Ma, Dawei (2024) Novel 6-Hydroxy Picolinohydrazide Ligands Promoted a Highly Efficient Cu(I)-Catalyzed Hydroxylation Reaction with Water. Angewandte Chemie. International edition.

Xue, Lian, Jie, Caitlin, Desrayaud, Sandrine and Auberson, Yves (2024) Developing Low Molecular Weight PET and SPECT Imaging Agents. ChemMedChem : chemistry enabling drug discovery.

Y

Yang, Junzheng, Buchanan, Natasha, Lima, Erika, Banks, Angela, Sluch, Valentin M., Fan, Lin, Leehy, Barrett, Arellano, Ivana, Qiu, Yubin, Klokman, Garrett, Hanks, Shawn, Vrouvlianis, Joanna, Davis, Venessa, Wu, Rake, Danilack, Aaron and Rice, Dennis (2024) A spontaneous mutation in ADIPOR1 causes retinal degeneration in mice. bioRxiv ( https://www.biorxiv.org).

Yi, Xiang, Kleinbeck-Riniker, Florian, Chang, Charlene, Boghospor, Lorita, Gomes, Sandy, Alvizo, Oscar, Allmendinger, Thomas, Fell, Jason, Subramanian, Nandhitha, Li, Michelle, Garcia, Ravi, Riggins, James, Entwistle, David, Richter, Yvonne, Gschwend, Daniel, Lauener, Liam, Schlama, Thierry, Ruch, Thomas, Peat, Thomas S. and Lebhar, Helene (2024) Enhancing the imine reductase activity of a promiscuous glucose dehydrogenase for scalable manufacturing of a chiral neprilysin inhibitor precursor. ACS Catalysis, 14 (9). pp. 7087-7096. ISSN 2155-54352155-5435

Z

Zhang, Alan, Seiss, Katherine, Laborde, Laurent, Guthy, Daniel Alexander, Lanter, Mylene, Lorber, Julien, Vulpetti, Anna, Hebach, Christina, Zoller, Thomas, Tschantz, Bill, Hollingworth, Greg, D'Alessio, Tony, Ferretti, Stephane Raymond, Karpov, Alexei and Burger, Matthew (2024) Design, Synthesis, In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79 targeted Antibody-Drug Conjugates. Bioconjugate chemistry. ISSN 1520-4812; 1043-1802

Zhou, Yu, Priya, Sonal and Ong, Joseph (2024) Characterizing Glycosylation of Adeno-Associated Virus Serotype 9 Capsid Proteins Generated from HEK293 Cells through Glycopeptide Mapping and Released Glycan Analysis. Microorganisms, 12 (5). p. 946. ISSN 2076-2607

Zhu, Dennis, Qu, Yang and Ye, Ning (2024) Automated Carcinogenic Potency Categorization Approach for Nitrosamine Drug Substance-related Impurities. Current Green Chemistry. ISSN 1463-92621463-9270

Zimmermann, Manuela, Baillie, Mark, Kormaksson, Matthias, Ohlssen, David and Sechidis, Kostas (2024) All that glitters is not gold: Type-I error controlled variable selection from clinical trial data. Clinical Pharmacology & Therapeutics, 115 (4). pp. 774-785. ISSN 0009-92361532-6535

Zink, Leah (2024) RNA-seq for detection of foreign RNA in CHO cell culture. University of Heidelberg, internal report of internship at Novartis.

Zoeller, Konstantin (2024) Continuous manufacturing: Implementation of multiple, deliberate interruptions of a virus removal filtration process. PDA Journal, 78 (2). pp. 196-205. ISSN 1948-2124