Vostiarova, Helena and Engelhardt, Volker (2024) EBF project: promoting replacement of preclinical matrix for IGM assays. not known at this stage.

Abstract

We have generated some data for the EBF (The European Bioanalysis Forum) project - an experiment to check the use of surrogate matrix for non-clinical assay set up and sample analysis for biotherapeutics (mAbs, therapeutic proteins). The goal is to evaluate for which assay types (ELISA, MSD, others, also different assay formats like free and total PK) the specific animal matrix could be substituted by a more abundant surrogate matrix, e.g. horse serum. This strategy would supports 3R implementation.
In this experiment we used Novartis compound (only nick name will be shared, not NVS code) and we would also share some general description of bioanalytical assay.

Item Type:	Article
Date Deposited:	30 Apr 2024 00:46
Last Modified:	30 Apr 2024 00:46
URI:	https://oak.novartis.com/id/eprint/52591