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Manganese(I)-Catalyzed Functionalization of Tryptophan on Water

Gallou, Fabrice (2024) Manganese(I)-Catalyzed Functionalization of Tryptophan on Water. Synlett, 35 (8). pp. 903-907.


The manganese(I)-catalyzed allylation of the amino acid tryptophan was realized under mild conditions using water as a sustainable and nonhazardous reaction medium instead of classical organic solvents. Synthetically useful α,β-unsaturated esters could be accessed by reaction with Morita-Baylis-Hillman (MBH) adducts following a direct C‒H activation approach. The robustness of this procedure was reflected by kinetic analysis at different reaction temperatures and reduced catalyst loadings.

Item Type: Article
Date Deposited: 18 Jun 2024 00:45
Last Modified: 18 Jun 2024 00:45