Furet, Pascal, Caravatti, Giorgio, Guagnano, Vito, Lang, Marc, Meyer, Thomas and Schoepfer, Joseph (2008) Entry into a new class of protein kinase inhibitors by pseudo ring design. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 897-900. ISSN 1464-3405

Abstract

A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Kinase; Scaffold morphing; Pseudo ring
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 13:51
Last Modified:	14 Dec 2009 13:51
URI:	https://oak.novartis.com/id/eprint/918