Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.
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Peukert, Stefan, Sun, Yingchuan, Zhang, Rui, Hurley, Brian, Sabio, Michael, Shen, Xiaoyu, Gray, Christen, Dzink-Fox, Joann, Tao, Jianshi, Cebula, Regina and Wattanasin, Sompong (2008) Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. Bioorganic & Medicinal Chemistry Letters, 18 (6). pp. 1840-1844. ISSN 1464-3405
Abstract
Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure-activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | UPPS inhibitor; Undecaprenyl pyrophosphate synthase; Antibacterial |
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| Date Deposited: | 14 Dec 2009 13:51 |
| Last Modified: | 31 Jan 2013 01:03 |
| URI: | https://oak.novartis.com/id/eprint/910 |