Grondine, Melissa, Gunderson, Karl, Reilly, John, Twomey Iii, Joseph, Vandenberg, Jennifer and Wang, Bing (2014) A combined approach of ion chromatography and quantitative NMR to accurately determine counterion stoichiometry. Journal of Liquid Chromatography and Related Technologies, 37 (10). pp. 1453-1464. ISSN 1082-6076

Abstract

Early phase pharmaceutical research compounds must be fully characterized in order to have confidence in any testing results. Traditional methods such as HPLC/MS do not give any indication of counterion presence or identity for many common counterions such as trifluoroacetate, acetate, or succinate. Herein, we describe a combined approach of ion chromatography and quantitative nuclear magnetic resonance spectroscopy in order to identify and quantify counterions in research samples of limited quantity. Forty-two research samples were analyzed and compared for trifluoroacetate, acetate, and succinate salts. Copyright © Taylor & Francis Group, LLC.

Item Type:	Article
Keywords:	Anions Cations Counterions Drug discovery Ion chromatography Nuclear magnetic resonance
Date Deposited:	18 Oct 2017 00:45
Last Modified:	25 Jan 2019 00:46
URI:	https://oak.novartis.com/id/eprint/8502