Telford, John L (2008) Bacterial genome variability and its impact on vaccine design. Cell host & Microbe, 3 (6). pp. 408-416. ISSN 1934-6069

Abstract

The majority of currently available successful vaccines induce host responses against antigens that are highly conserved in the targeted pathogens. The diphtheria, tetanus, and pertussis vaccines confer protection by inducing neutralizing antibodies to the conserved bacterial toxins that are the major virulence factors. The Hemophilus influenzae B vaccine induces responses to conserved epitopes in the sugar structure of the bacterial capsular polysaccharide. However, the efficacy of more recently developed vaccines is limited by antigen variation, which also presents a challenge for future vaccine development. This review will explore bacterial genome variability and its impact on vaccine development.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... http://www.cell.com/cell-host-microbe/re... doi:10.1016/j.chom.2008.05.004
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... http://www.cell.com/cell-host-microbe/re... doi:10.1016/j.chom.2008.05.004
Date Deposited:	14 Dec 2009 13:53
Last Modified:	14 Dec 2009 13:53
URI:	https://oak.novartis.com/id/eprint/822