Genovino, Julien, Lagu, Bharat, Toure, Bakary-Barry and Wang, Kate (2012) Synthesis of sterically hindered enamides via a Ti-mediated condensation of amides with aldehydes and ketones. Chemical Communications, 48 (53). pp. 6735-6737. ISSN 1359-7345

Abstract

The first TiCl(4)-mediated condensation of secondary amides with aldehydes and ketones has been achieved. The reaction proceeds at room temperature and is complete within 5 h in most cases. The optimized procedure used 5 equiv of an amine base hinting that the in situ activation of both the amide and the Lewis acid is required. The reaction affords polysubstituted (E)-enamides.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/22643...
Keywords:	enamides, titanium tetrachloride, carbonyl compounds, amides
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/22643...
Date Deposited:	13 Oct 2015 13:14
Last Modified:	13 Oct 2015 13:14
URI:	https://oak.novartis.com/id/eprint/8040