Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists
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Koller, Manuel, Carcache, David, Orain, David, Ertl, Peter, Behnke, Dirk, Desrayaud, Sandrine, Laue, Grit and Vranesic, Ivan-Toma (2012) Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists. Bioorganic Medicinal Chemistry Letters, 22. pp. 6454-6459.
Official URL: http://www.elsevier.com
Abstract
1H-pyrrolo[2,3-c]pyridine-7-carboxamides constitute a new series of allosteric mGluR5 antagonists. Variation of the substituents attached to the heterocyclic scaffold allowed improving the physico-chemical parameters for optimization of the aqueous solubility while retaining high in vitro potency.
Item Type: | Article |
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Keywords: | Excitatory amino acids; metabotropic glutamate receptor; mGluR5; negative allosteric modulator; 1H-pyrrolo[2,3-c]pyridine-7-carboxamides |
Date Deposited: | 03 May 2016 23:45 |
Last Modified: | 03 May 2016 23:45 |
URI: | https://oak.novartis.com/id/eprint/8018 |