ROLE OF SPHINGOSINE 1-PHOSPHATE AND LYSOPHOSPHATIDIC ACID IN FIBROSIS
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Pyne, Nigel J., Dubois, Gerald and Pyne, Susan (2012) ROLE OF SPHINGOSINE 1-PHOSPHATE AND LYSOPHOSPHATIDIC ACID IN FIBROSIS. Biochimica et Biophysica Acta. ISSN 0006-3002
Abstract
This review highlights a significant role for sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) in many different types of fibrosis and their therapeutic potential. Indeed, the development of effective LPA receptor 1 (LPA1) antagonists and a neutralising anti-S1P antibody that is currently in Phase 1 clinical trials for treatment of age related macular degeneration indicate that translational progress to the clinic is well advanced. However, both LPA and S1P are involved in the multi-process pathogenesis of fibrosis, being implicated in promoting differentiation of fibroblasts to myofibroblasts, epithelial-mesenchymal transition and fibrocyte homing to fibrotic lesions. These processes provide new opportunities for drug intervention targeted at S1P and LPA biology.
| Item Type: | Article |
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| Additional Information: | T his is a review with no proprietary data included. |
| Keywords: | sphingosine 1-phosphate, lysophosphatidic acid, fibrosis, TGFβ, signaling, connective tissue growth factor |
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| Date Deposited: | 13 Oct 2015 13:14 |
| Last Modified: | 13 Oct 2015 13:14 |
| URI: | https://oak.novartis.com/id/eprint/7497 |