Tichý, Michal, Pohl, Radek, Hocek, Michal, Shi, Pei-Yong, Yokokawa, Fumiaki, Xu, Haoying and Chen, Yen Liang (2012) Synthesis of 4,6-Disubstituted Pyrimido[4,5-b]indole Ribonucleosides through Regioselective Cross-coupling Reactions. Bioorganic & Medicinal Chemistry, 20 (20). pp. 6123-6133. ISSN 0968-0896

Abstract

A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Some of these compounds displayed antiviral activity against Dengue virus.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/22985... http://dx.doi.org/10.1016/j.bmc.2012.08....
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/22985... http://dx.doi.org/10.1016/j.bmc.2012.08....
Date Deposited:	13 Oct 2015 13:14
Last Modified:	13 Oct 2015 13:14
URI:	https://oak.novartis.com/id/eprint/7385