Microwave Mediated Suzuki-Miyaura Couplings of S- and Ortho-Substituted Methylphenylboronic Acid Esters
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Press, Neil, baltus, christine B and Spencer, John (2012) Microwave Mediated Suzuki-Miyaura Couplings of S- and Ortho-Substituted Methylphenylboronic Acid Esters. Synlett, 23 (17). pp. 2477-2480. ISSN 0936-5214
Official URL: https://www.thieme-connect.de/DOI/DOI?10.1055/s-00...
Abstract
Hitherto unsuccessful cross couplings of ortho-substituted or thioether-substituted methylphenylboronates have been achieved, under microwave conditions, enabling the synthesis of a library of novel biaryls. Tetrakis(triphenylphosphine)palladium and various bases e.g. sodium carbonate or cesium fluoride were found to mediate the crucial C-C bond forming cross coupling reaction.
Item Type: | Article |
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Additional Information: | Paper from CASE collaboration - no proprietary structures or research |
Keywords: | Microwave, Suzuki-Miyaura, couplings, methylphenylboronic acid, palladium, catalysis, cross-coupling, biaryls, microwaves |
Date Deposited: | 13 Oct 2015 13:14 |
Last Modified: | 13 Oct 2015 13:14 |
URI: | https://oak.novartis.com/id/eprint/7372 |