Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.
Tools
Furet, Pascal, Imbach, Patricia, Noorani, Maria, Koeppler, Juergen, Laumen, Kurt, Lang, Marc, Guagnano, Vito, Fuerst, Peter, Roesel, Johannes, Zimmermann, Johann and Garcia-Echeverria, Carlos (2004) Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design. Journal of Medicinal Chemistry, 47 (20). pp. 4810-4813. ISSN 0022-2623
Official URL: http://pubs.acs.org/doi/abs/10.1021/jm049660v
Abstract
Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.
Item Type: | Article |
---|---|
Related URLs: | |
Additional Information: | archiving not formally supported by this publisher |
Related URLs: | |
Date Deposited: | 14 Dec 2009 13:55 |
Last Modified: | 31 Jan 2013 01:08 |
URI: | https://oak.novartis.com/id/eprint/728 |