Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.
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Cryan, John F. and Kaupmann, Klemens (2005) Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends in Pharmacological Sciences, 26 (1). pp. 36-43. ISSN 0165-6147
Abstract
GABA, the main inhibitory neurotransmitter in the brain, regulates many physiological and psychological processes. Thus, dysfunction of the GABA system is implicated in the pathophysiology of several neuropsychiatric disorders, including anxiety and depression. However, the role of GABA(B) receptors in behavioural processes related to these disorders has not been resolved. GABA(B) receptors are G-protein-coupled receptors that function as heterodimers of GABA(B(1)) and GABA(B(2)) subunits. In addition to highly selective agonists and antagonists, novel GABA(B) receptor tools have been developed recently to further assist elucidation of the role of GABA(B) receptors in CNS function. These include mice that lack functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depression.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 14 Dec 2009 13:55 |
| Last Modified: | 31 Jan 2013 01:09 |
| URI: | https://oak.novartis.com/id/eprint/699 |