Wattanasin, Sompong, Kallen, Joerg, Myers, Stewart, Guo, Qin, Sabio, Michael, Ehrhardt, Claus, Albert, Rainer, Hommel, Ulrich, Weckbecker, Gisbert, Welzenbach, Karl and Weitz Schmidt, Gabriele (2005) 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters, 15 (4). pp. 1217-1220. ISSN 0960-894X

Abstract

1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2004.11.072
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Integrin; LFA-1; Diazepanediones; I-domain; L-site binding
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2004.11.072
Date Deposited:	14 Dec 2009 13:56
Last Modified:	31 Jan 2013 01:10
URI:	https://oak.novartis.com/id/eprint/672