The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector
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Diagana, Thierry, Yeung, Bryan and Sauerwein, Robert (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804
Abstract
The global malaria agenda has undergone a reorientation from control of clinical cases to entirely eradicating malaria. For that purpose, a key objective is blocking transmission of malaria parasites from humans to mosquito vectors. The new antimalarial drug candidate NITD609 was evaluated for its transmission reducing potential using a suite off in vitro assays. Using a microscopic readout NITD609 was found to inhibit in a dose dependent-fashion the induction and maturation of Plasmodium falciparum gametocytes in vitro. In addition, using the standard membrane feeding assay, NITD609 was also found to be a very effective drug in reducing transmission to Anopheles stephensi mosquito vector. Collectively our data suggest that NITD609 may have potential as a transmission blocking drug in addition to its therapeutic activity against asexual P. falciparum malaria parasites.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); but on personal or university-hosted websites only |
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| Date Deposited: | 13 Oct 2015 13:14 |
| Last Modified: | 13 Oct 2015 13:14 |
| URI: | https://oak.novartis.com/id/eprint/6462 |