Receptor-specific regulation of ERK1/2 activation by members of the ‘Free Fatty Acid Receptor’ family
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Seljeset, Sandra and Siehler Wagner, Sandra (2012) Receptor-specific regulation of ERK1/2 activation by members of the ‘Free Fatty Acid Receptor’ family. Journal of Receptors & Signal Transduction, 32 (4). pp. 196-201. ISSN 1079-9893
Abstract
The ‘free fatty acid receptor’ (FFAR) GPR41 strongly couples to ERK1/2 activation, while the coupling of GPR40 and GPR43 was weaker. JNK and p38MAPK were weakly activated by FFARs. All three receptors activated ERK1/2 fully or partially via Gi/o and Rac. PI3K was relevant for GPR40- and GPR41-mediated ERK1/2 activation, and Src was essential for GPR40- and GPR43-induced activation. Raf-1 was not involved in the GPR43-triggered activation. These results demonstrate that GPCRs belonging to the same family can regulate ERK1/2 activation by different receptor-specific mechanisms.
| Item Type: | Article |
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| Keywords: | GPCR, FFAR, MAPK, ERK1/2 |
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| Date Deposited: | 13 Oct 2015 13:14 |
| Last Modified: | 13 Oct 2015 13:14 |
| URI: | https://oak.novartis.com/id/eprint/6343 |