Becherelli, Marco, Tao, Jianshi and Ryder, Neil (2013) Involvement of heat shock proteins in Candida albicans biofilm formation. Journal of Molecular Microbiology and Biotechnology. ISSN 1464-1801

Abstract

Hsp90 has been pursued as a target for the treatment of fungal diseases. Here we investigated the involvement of hsp90 in C. albicans biofilm. Biofilm formation was greatly reduced upon low levels of Hsp90 inhibitors 17-DMAG treatment. Further qRT-PCR experiments confirmed that hsp genes are overexpressed during the initial stage of biofilm formation. Our results suggest that hsp proteins could have a role in C.albicans biofilm development.

Item Type:	Article
Keywords:	hsp90, biofilm, candida albicans
Date Deposited:	13 Oct 2015 13:14
Last Modified:	13 Oct 2015 13:14
URI:	https://oak.novartis.com/id/eprint/6261