Rene, Olivier, Fuentes Gutierrez, Alfredo and Wu, Kaira (2025) Palladium-Catalyzed α‑Arylation of Boc-Protected Lactams Using 2,2,6,6-Tetramethylpiperidine·ZnCl·LiCl. Synlett.

Abstract

We report general conditions for the palladium-catalyzed α-arylation of Boc-protected lactams using TMP·ZnCl·LiCl as base, eliminating the need for preformed zinc amides. The method is compatible with various 5- and 6-membered lactams and a broad range of aryl bromides. These operationally simple conditions enable efficient access to α-arylated lactams, streamlining SAR exploration in medicinal chemistry.

Item Type:	Article
Date Deposited:	17 Jan 2026 00:46
Last Modified:	17 Jan 2026 00:46
URI:	https://oak.novartis.com/id/eprint/59276