Stöcklin, Reto and Vorherr, Thomas (2011) Future perspectives of venoms for drug discovery. PharManufacturing.

Abstract

Venoms have been regarded as an interesting source for screening difficult-to-address pharmaceutical targets like ion channels, transmembrane or circulating proteins for quite some time. Moreover, recent developments open up new opportunities to better exploit well-structured toxins - so called “mini-proteins” that we also like to refer to as “picologics” - in a more general way for lead discovery and drug development. In particular, progress in throughput and the first results from the next generation of genome/transcriptome analyses and systems biology investigations widen the scope of an integrated understanding of global transcriptional activity in venom glands. As a result, natural products from venoms are thought to represent a sustainable source of molecules for addressing a wider range of targets, and thus enable a more systematic approach to the identification of new peptide therapeutic candidates.

Item Type:	Article
Additional Information:	Review
Keywords:	venom libraries, peptides, drug dsicovery
Date Deposited:	13 Oct 2015 13:14
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/5894