Dev, Kumlesh K. and Henley, Jeremy M. (2006) The schizophrenic faces of PICK1. Trends in Pharmacological Sciences, 27 (11). pp. 574-579. ISSN 0165-6147

Abstract

Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for pharmacological manipulation of PICK1.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.tips.2006.09.007
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.tips.2006.09.007
Date Deposited:	14 Dec 2009 13:57
Last Modified:	14 Dec 2009 13:57
URI:	https://oak.novartis.com/id/eprint/589