Martin, Benjamin, Gabriel, Pablo, Allmendinger, Simon, Furegati, Markus, Noel, Timothy, Findlay, Michael, Lukas, Florian, Rizzo, Francesca and Liu, Junsong (2025) Graphitic carbon nitride/nickel dual catalysis for decarboxylative synthesis of unsymmetrical ketones from keto acids. Green Chemistry.

Abstract

The emergence of photoredox catalysis in synthetic chemistry has brought a plethora of new synthetic methodologies to the modern chemist’s toolbox, enabling a range of novel synthetic disconnections. In particular, metallaphotoredox chemistry, the merger of transition-metal catalysis and photoredox catalysis, has allowed the novel synthesis of previously elusive molecular scaffolds and the utilisation of a wide variety of potential coupling partners. In an effort to expand upon our earlier work, we investigated the use of α-keto carboxylic acids as a source of acyl radicals with a commercial gCN photocatalyst, furnishing ketones after nickel-catalysed coupling with aryl halides, avoiding the use of iridium-based photocatalysts.

Item Type:	Article
Keywords:	graphitic carbon nitride • decarboxylation • heterogeneous photocatalysis • metallaphotoredox • nickel
Date Deposited:	08 Nov 2025 00:45
Last Modified:	08 Nov 2025 00:45
URI:	https://oak.novartis.com/id/eprint/57795