Doleckova, Iva, Vidovic, Tinka, Jandova, Lenka, Gretzmeier, Christine, Navarini, Alexander A, MacArthur, Michael R, Goksel, Orcun, Nyström, Alexander and Ewald, Collin Y (2024) Calpain Inhibition Protects against UVB-Induced Degradation of Dermal-Epidermal Junction-Associated Proteins. The Journal of investigative dermatology, 144 (9). 2103-2107.e2. ISSN 1523-1747

Abstract

To the Editor
The skin is a highly regenerative tissue that harbors multiple reservoirs of stem cells, enabling it to efficiently repair and regenerate (
Fuchs, 2008
). However, despite its regenerative capacity, the skin undergoes aging, leading to compromised barrier function, reduced mechanoresilience, and impaired wound healing (
Quan, 2023
). Histological analyses have indicated that alterations in the extracellular matrix of the skin are key features of aging (
Quan, 2023
). These alterations affect the load-bearing dermal interstitial extracellular matrix through reduced collagen levels and increased fragmentation of collagen and elastin fibers (
Quan, 2023
). In addition, the dermal–epidermal junction (DEJ) is significantly affected during skin aging (
Langton et al, 2016
). Hemidesmosomes (HDs) are multiprotein attachment structures, which at the DEJ are composed of integrin ⍺6β4, collagen XVII, and CD151 at the basal keratinocyte plasma membrane and intracellularly; plectin; and BPAG1, BP230, or dystonin (
Ewald and Nyström, 2023
).

Item Type:	Article
Date Deposited:	28 Sep 2024 00:45
Last Modified:	28 Sep 2024 00:45
URI:	https://oak.novartis.com/id/eprint/55287