Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Condensin I folds the Caenorhabditis elegans genome.

Das, Moushumi, Semple, Jennifer I, Haemmerli, Anja, Volodkina, Valeriia, Scotton, Janik, Gitchev, Todor, Annan, Ahrmad, Campos, Julie, Statzer, Cyril, Dakhovnik, Alexander, Ewald, Collin Y, Mozziconacci, Julien and Meister, Peter (2024) Condensin I folds the Caenorhabditis elegans genome. Nature genetics, 56 (8). pp. 1737-1749. ISSN 1546-1718

Abstract

The structural maintenance of chromosome (SMC) complexes-cohesin and condensins-are crucial for chromosome separation and compaction during cell division. During the interphase, mammalian cohesins additionally fold the genome into loops and domains. Here we show that, in Caenorhabditis elegans, a species with holocentric chromosomes, condensin I is the primary, long-range loop extruder. The loss of condensin I and its X-specific variant, condensin I, leads to genome-wide decompaction, chromosome mixing and disappearance of X-specific topologically associating domains, while reinforcing fine-scale epigenomic compartments. In addition, condensin I/I inactivation led to the upregulation of X-linked genes and unveiled nuclear bodies grouping together binding sites for the X-targeting loading complex of condensin I. C. elegans condensin I/I thus uniquely organizes holocentric interphase chromosomes, akin to cohesin in mammals, as well as regulates X-chromosome gene expression.

Item Type: Article
Date Deposited: 28 Sep 2024 00:45
Last Modified: 28 Sep 2024 00:45
URI: https://oak.novartis.com/id/eprint/55286

Search