Walles, Markus (2024) Meeting report of the 5th European Biotransformation Workshop. Xenobiotica, sep. pp. 1-10. ISSN 10.1080/00498254.2024.2400112

Abstract

Challenges, strategies and new technologies in the field of biotransformation were presented and discussed at the 5th European Biotransformation Workshop, which was held on March 14, 2024 on the Novartis Campus in Basel, Switzerland.
2. In this meeting report we summarise the presentations and discussions from this workshop.
3. The topics covered are listed below:
• Advances in understanding drug induced liver injury (DILI) risks of carboxylic acids and targeted covalent inhibitors
• Biotransformation of oligonucleotide-based therapeutics including automated software tools for metabolite identification
• Recent advances in metabolite synthesis
• Qualification and validation of a new compact Low Energy Accelerator Mass Spectrometry (LEA) system for metabolite profiling
Keywords: unusual biotransformation reactions, acyl glucuronides, acyl CoA conjugates, DILI risks, biotransformation of oligonucleotides, Genedata software for MS data processing of oligonucleotides, AMS, Mass spectrometry imaging

Item Type:	Article
Keywords:	biotransformation, ams, DILI, reactive metabolites
Date Deposited:	26 Sep 2024 00:45
Last Modified:	26 Sep 2024 00:45
URI:	https://oak.novartis.com/id/eprint/55126