O Meadhra, Ruairi, Fleury, Christian, Guelat, Bertrand and Venturoni, Francesco (2024) Acetonitrile Regeneration from Oligonucleotide Production Waste Streams. Organic Process Research & Development, n/a (n/a). A-N. ISSN 1083-61601520-586X

Abstract

A distillation concept is described to process organic and aqueous waste streams from an oligonucleotide process to regenerate 85% of the acetonitrile contained in the wastes, for re-introduction back into the oligonucleotide process. Careful selection of the streams to send to regeneration based on their acetonitrile content was shown to simplify the number of processing steps and minimize the size of the equipment required for regeneration. Availability of accurate vapor-liquid equilibrium was shown key to designing the number of processing steps, the operating conditions and to calculate purification performance. A modified classical two-column distillation pressure-swing dewatering system, with an intermediate-pressure column for separation of light boilers was shown to effectively purify and dewater acetonitrile to the required specifications. Use is made of AspenPlus software to generate VLE data and simulate process alternatives.

Item Type:	Article
Date Deposited:	17 Sep 2024 00:45
Last Modified:	17 Sep 2024 00:45
URI:	https://oak.novartis.com/id/eprint/54561