Libertini, Silvana, Jadlowsky, Julie, Lanz, Tom, Mihalcik, Lauren and Pizzurro, Daniella (2024) Genotoxicity evaluation of gene therapies: A report from the International Workshop on Genotoxicity Testing (IWGT) 2022. Environmental and molecular mutagenesis. ISSN 1098-2280

Abstract

At the 8th International Workshop on Genotoxicity Testing meeting in Ottawa, in August 2022, a plenary session was dedicated to the genotoxicity risk evaluation of gene therapies, including insertional oncogenesis and off-target genome editing. This brief communication summarizes the topics of discussion and the main insights from the speakers. Common themes included recommendations to conduct tailored risk assessments based on a weight-of-evidence approach, to promote data sharing, transparency, and cooperation between stakeholders, and to develop state-of-the-art validated tests relevant to clinical scenarios.

Item Type:	Article
Date Deposited:	19 Nov 2024 00:45
Last Modified:	19 Nov 2024 00:45
URI:	https://oak.novartis.com/id/eprint/54523