Fairhurst, Robin (2024) Adventures with the β2-adrenoceptor Receptor: A Career Long Interest in Agonising One of the Most Widely Studied GPCRs. Chimia, 78 (7-8). pp. 483-498. ISSN 0009-4293

Abstract

Drug discovery is a multi-disciplinary effort in which groups with expertise in a range of areas combine in a unified way to achieve a common goal: to deliver a clinical candidate to evaluate a hypothesis for improving human health. As a medicinal chemist this environment has provided multiple opportunities to be involved in cross-discipline interactions that have been both rewarding and led to outcomes that would not have been possible without an intimate interdisciplinary curiosity. Within this article I aim to share some of my experiences with the β2-adrenoceptor that have fostered such synergistic relationships with several disciplines, but in particular with in vitro pharmacologists looking at different ways to stimulate this G protein-coupled receptor (GPCR). This interest now spans over a quarter of a century and has been intertwined with the delivery of three clinical candidates.

Item Type:	Article
Keywords:	Humans Receptors, Adrenergic, beta-2 Drug Discovery Receptors, G-Protein-Coupled Adrenergic beta-2 Receptor Agonists
Date Deposited:	16 Jan 2025 00:45
Last Modified:	16 Jan 2025 00:45
URI:	https://oak.novartis.com/id/eprint/54131