A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas disease
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Saldivia Concepcion, Manuel Alejandro, C A Lima, Ana Paula and Mottram, Jeremy (2024) A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas disease. Trends in parasitology, 40 (3). pp. 211-213. ISSN 14714922
Official URL: https://www.sciencedirect.com/science/article/pii/...
Abstract
In recent years, the drug discovery pipeline for leishmaniasis and trypanosomiasis has been filling with a number of novel chemical entities (NCE) with known mechanisms of action (MoA). Recent work from González [1] and Braillard et al. [2] reports a Cytochrome bc1 complex inhibitor as another promising preclinical candidate for visceral leishmaniasis (VL) and in combination with a current drug, benznidazole, for chronic Chagas disease (CCD).
Item Type: | Article |
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Date Deposited: | 09 Apr 2024 00:45 |
Last Modified: | 09 Apr 2024 00:45 |
URI: | https://oak.novartis.com/id/eprint/53071 |