Pharmacokinetics of rec-hirudin in healthy volunteers after intravenous administration.
Cardot, J M, Lefevre, Gilbert and Godbillon, J A (1994) Pharmacokinetics of rec-hirudin in healthy volunteers after intravenous administration. Journal of pharmacokinetics and biopharmaceutics, 22 (2). pp. 147-156. ISSN 0090-466X
Abstract
The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39,393) in healthy volunteers after iv administration was investigated on the basis of the data from five different studies. A total of 77 plasma profiles following a single iv bolus dose of either 0.1, 0.3, 0.5, or 1 mg/kg of rec-hirudin was used for the evaluation. Plasma concentrations and especially AUC were proportional to the dose. Kinetics of rec-hirudin after a bolus iv injection were best described by a three-compartment open model. Mean apparent terminal half-life was 2.8 hr and the total clearance 0.138 L/hr per kg.
Item Type: | Article |
---|---|
Date Deposited: | 28 Jan 2012 00:45 |
Last Modified: | 01 Feb 2013 00:46 |
URI: | https://oak.novartis.com/id/eprint/5286 |