Picci, Marie (2024) Towards more tolerable and painless subcutaneous administration: review of contributing factors for improving combination product design. Towards more tolerable and painless subcutaneous administration: review of contributing factors for improving combination product design, 209 (209). ISSN 115301

Abstract

Subcutaneous (SC) injections can be associated with a subjective level of local pain and discomfort, which may affect treatment adherence and overall patient experience. With innovations increasingly focusing on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence SC injection pain. As part of the work of the SC Drug Delivery and Development Consortium, this manuscript provides a comprehensive review of known attributes from published literature that contribute to SC injection pain/discomfort from three perspectives: (1) device and delivery factors that cause physical pain, (2) formulation factors that trigger biophysical/biochemical pain responses, and (3) human factors impacting pain perception. Leveraging the Consortium’s collective expertise, we also provide an assessment of the comparative and interdependent factors likely to impact SC injection pain, and offer expert insights and future perspectives to fill identified gaps in knowledge to help advance the development of patient-centric and well tolerated high dose/high volume SC drug delivery solutions.

Item Type:	Article
Keywords:	Subcutaneous (SC) injections can be associated with local pain and discomfort. Multiple intertwined factors contribute to SC injection site pain/discomfort. Device, delivery, and formulation factors influencing injection pain are reviewed.
Date Deposited:	10 May 2024 00:46
Last Modified:	10 May 2024 00:46
URI:	https://oak.novartis.com/id/eprint/52576