Knez, Benjamin (2024) Viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions with proline analogues. International journal of pharmaceutics. ISSN 03785173

Abstract

Investigation of several compounds based on Proline with a focu on their viscosity reducing effects. We aim to research the mechanism of viscosity reduction of mAb solutions using small molecule excipients and find new, nontoxic viscosity reducers with stabilizing effect on the model mAb. If successful, discovery of effective viscosity reducers will facilitate the development of mAb formulations for subcutaneous administration and contribute to an approachable and sustainable treatment with biological medicines. Lastly, molecular dynamics simulations have been performed to evaluate the suitability of such methods in predicting viscosity reducing effects.

Item Type:	Article
Keywords:	monoclonal antibodies, subcutaneous administration, viscosity, proline, high concentration
Date Deposited:	12 Apr 2024 00:45
Last Modified:	12 Apr 2024 00:45
URI:	https://oak.novartis.com/id/eprint/52320