Zawel, Leigh (2004) Teaching cancer cells to die. Journal of Cellular Biochemistry, 92 (4). pp. 651-655. ISSN 0730-2312

Abstract

Tumor cells have evolved numerous mechanisms to thwart apoptosis. As our understanding of the machinery which regulates cell-death evolves, these apoptotic defects have fallen into the crosshairs of cancer drug developers. The issues raised in exploiting these alterations for therapeutic benefit are discussed.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
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Keywords:	apoptosis; BCL2; IAPs; Smac; TRAIL; XIAP
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 14:07
Last Modified:	31 Jan 2013 01:31
URI:	https://oak.novartis.com/id/eprint/52