Brocklehurst, Cara (2018) Supplimentary information for: Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki–Miyaura and Buchwald–Hartwig Cross-Couplings in Water. Organic Process Research & Development, 22 (10). pp. 1453-1457. ISSN 1083-61601520-586X

Abstract

A screening method to evaluate Suzuki–Miyaura and Buchwald–Hartwig coupling reactions under aqueous surfactant conditions has been established, leading to high yielding and highly selective Suzuki–Miyaura and Buchwald–Hartwig reactions under mild reaction temperatures and ecologically improved conditions. The screening method highlighted the utility of Buchwald–Hartwig third generation precatalysts for unprecedented high conversion Buchwald–Hartwig C–N coupling reactions in water.

Item Type:	Article
Date Deposited:	02 Aug 2023 00:45
Last Modified:	02 Aug 2023 00:45
URI:	https://oak.novartis.com/id/eprint/50994