Keuper-Navis, Marit, Walles, Markus, Poller, Birk, Myszczyszy, Adan, Van der Made, Thom, Donkers, Joanne, Eslami Amirabadi, Hossein, Wilmer, Martijn, Spee, Bart, Masereeuw, Rosalinde and Van de Steeg, Eviata (2023) The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development. Pharmacological research. p. 106853. ISSN 1096-1186

Abstract

Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed, with a focus on the functionality of the models and the application in current drug development practice. Multi-OoC models demonstrating the application for pharmacokinetic (PK) studies are summarized and existing challenges are identified. Physiological parameters for a minimal viable platform of a multi-OoC model to study PK are provided, together with PK specific read-outs and recommendations for relevant reference compounds to validate the model. Finally, the translation to in vivo PK profiles is discussed, which will be required to routinely apply OoC models during drug development.

Item Type:	Article
Date Deposited:	01 Sep 2023 00:45
Last Modified:	01 Sep 2023 00:45
URI:	https://oak.novartis.com/id/eprint/49825