Coppola, Gary, Damon Ii, Robert, Eskesen, J, France, Dennis and Paterniti, James (2006) Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 113-117. ISSN 0960-894X

Abstract

A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil. The optimal analogue (HDL376) was shown to raise HDL cholesterol in the rat, hamster, dog, and monkey models.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2005.09.034
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2005.09.034
Date Deposited:	14 Dec 2009 13:59
Last Modified:	14 Dec 2009 13:59
URI:	https://oak.novartis.com/id/eprint/496