Beckers, Maximilian, Fechner, Nikolas and Stiefl, Nikolaus (2022) Cover art to "25 years of small molecule optimization at Novartis: A retrospective analysis of chemical series evolution". Journal of chemical information and modeling, 62 (23). pp. 5849-6286.

Abstract

In the internal Novartis compound databases, a set of ~3000 chemical series has been retrospectively reconstructed. Using the registration dates of the compounds, the evolution over time of structural properties, ADMET and target activities during optimization of the compounds has been analyzed, which revealed multiple trends. Furthermore, general properties of the chemical series and their inter-relations are investigated.

Item Type:	Article
Date Deposited:	17 Jan 2023 00:45
Last Modified:	17 Jan 2023 00:45
URI:	https://oak.novartis.com/id/eprint/48855