Moraitis, Alexandra (2022) The function of 14-3-3 protein family and its connection with cancer review. University business..

Abstract

14-3-3 is a family of conserved acidic proteins. The 14-3-3 proteins are key modulators of
more than 200 proteins and these interactions occur by either a phosphorylation-dependant
or phosphorylation-independent manner. 14-3-3 target proteins are implicated in key
signalling pathways that control the cellular physiology including apoptosis, cell cycle,
differentiation, proliferation, and migration. Their important role in maintaining genome
integrity and correct cell cycle progression exemplifies how de-regulated 14-3-3 expression
and activity is an important event in cancer. Better understanding the complex interactions
14-3-3 have with their targets gives us new approaches in targeted cancer therapies.

Item Type:	Article
Date Deposited:	10 Aug 2022 00:46
Last Modified:	10 Aug 2022 00:46
URI:	https://oak.novartis.com/id/eprint/47646