Auberson, Yves, Lièvre, Akane, Desrayaud, Sandrine and Briard, Emmanuelle (2022) A practical approach to the optimization of positron emission tomography imaging agents for the central nervous system. Journal of labelled compounds & radiopharmaceuticals, 65 (13). pp. 343-350. ISSN 1099-1344

Abstract

The discovery of novel imaging agents for positron emission tomography (PET) relies on medicinal chemistry best practices, including a good understanding of molecular and pharmacological properties required for the acquisition of relevant, high-quality images. This short note reviews the characteristics of a series of clinically successful imaging agents, providing guidance for the optimization of such molecular tools. PET imaging plays an important role in staging disease and in helping clinical dose selection, which is critical for the efficient development of drug candidates.

Item Type:	Article
Keywords:	Radiopharmaceuticals Positron-Emission Tomography Central Nervous System
Date Deposited:	27 Dec 2022 00:45
Last Modified:	27 Dec 2022 00:45
URI:	https://oak.novartis.com/id/eprint/47524