Parmentier, Michael, Hoehn, Pascale, Marti, Roger, Dabros, Michal, Brodard, Pierre, Ferrari, Thomas, Blum, Caitlin and Amini-Rentsch, Lara (2022) Development, Validation, and Application of a Custom-Made Mini-Reaction Calorimeter for Thermal Safety Screening. Organic Process Research & Development. ISSN 1083-61601520-586X

Abstract

Before scaling up to production, it is of high im-portant to evaluate the potential of a reaction of leading to an undesired thermal degradation event. The use of large amount of compounds is usually required for calorimetry study. In this work, we re-port the development of a ml-scale reaction calorim-eter for reaction screening applications. The set-up was designed using lab-equipment and character-ized and validated with routine experiments. The results were accurate that we were able to observe trends in the measured reaction enthalpies depend-ing on the structure of the compounds in reaction with a strong base. The use of the micro scale tailor-made calorimeter is seen as very valuable for poten-tially highly energetic reactions where no data are available and to perform multiple experiments no using considerable amount of valuable material.

Item Type:	Article
Keywords:	Calorimeter, Sulfamidate, Thermal Safety, Micro Scale, reaction calorimeter
Date Deposited:	16 Sep 2022 00:46
Last Modified:	16 Sep 2022 00:46
URI:	https://oak.novartis.com/id/eprint/47516