Gallou, Fabrice (2022) Phosphine Ligand-Free Bimetallic Ni(0)Pd(0) Nanoparticles as a Catalyst for Facile, General, Sustainable, and Highly Selective 1,4-Reductions in Aqueous Micelles. ACS Appl. Mater. Interfaces, 14 (5). pp. 6754-6761.

Abstract

By harnessing the synergy between Ni(0), Pd(0), and aqueous micelle of proline-derived PS-750-M amphiphile,
phosphine ligand-free ultrasmall nanoparticles (NPs) of Ni(0)-Pd(0) are developed for highly selective 1,4-reductions of
enones. In NP, Ni(0)-bound Pd(0) atom found to only react with most electron-deficient double bond due to electron-rich
character of Pd and fine-tuning of its d-band. Most notably, NPs contain a minimal amount of Pd (Ni:Pd = 25:1) and are highly selective without affecting the different types of N-and O-benzyl, aldehyde, nitrile, and nitro functional groups. The catalytic selectivity is investigated on a broad range of substrates, including the gram scale reaction. Control experiment reveals Ni, Pd, and micelle of PS-750-M are required for higher selectivity. The metal-micelle binding was supported by a surface-enhanced Raman spectroscopy study of NPs and their components. Optical imaging, high-resolution transmission electron microscopy (HRTEM), and energy-dispersive X-ray spectroscopy (EDX) analyses were performed to reveal the formation of NPcontaining micelle or vesicles, NPs morphology, particle size distribution, and chemical composition, while X-ray photoelectron spectroscopy (XPS) measurements unveiled the oxidation state of each metal in bimetallic NP.

Item Type:	Article
Keywords:	micelle, Nanoparticles, sustainable
Date Deposited:	19 Apr 2022 00:45
Last Modified:	19 Apr 2022 00:45
URI:	https://oak.novartis.com/id/eprint/45667